Proteases

Details Proteases Proteases

2011-03-15

2011-03-15

Nashed, Nashaat T (Department: 1656)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C435S069100, C435S252300, C435S252310, C435S254110, C435S320100, C426S053000, C510S300000, C536S023200

Reexamination Certificate

active

07906310

ABSTRACT:
The invention relates to a novel class of serine proteases of peptidase family S2A or S1E that are stable in the presence of copper (Cu2+) and/or inhibited by copper only to a limited extent. Structural features of potential relevance for this effect are also disclosed. This class of proteases includes proteases derived fromBrachysporiella gayana, Nocardiopsis dassonvilleisubsp.dassonvillei, Nocardiopsis prasina, andNocardiopsis alba, but excludes the known proteases derived fromMetarhizium anisopliaeandNocardiopsissp. NRRL 18262. The invention also relates to DNA encoding such proteases, the expression thereof in a host cell, including animal and plant cells, as well as to the use thereof, e.g., in animal feed and in detergents. In particular, the invention relates to animal feed and animal feed additives, such as premix, incorporating these proteases together with 1-500 ppm Cu (in-feed-concentration).

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