Protease, reverse transcriptase and endonuclease of HIV-1 and RS

Details Protease, reverse transcriptase and endonuclease of HIV-1 and RS Protease, reverse transcriptase and endonuclease of HIV-1 and RS

1993-06-25

1996-03-19

Stone, Jacqueline M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 691, 4351723, 435212, 435219, 4353201, 435849, 930221, 935 38, 935 47, 935 73, C12P 2102, C12N 1548, C12N 1549, C12N 1570

Patent

active

055003559

ABSTRACT:
Disclosed is a method for producing retroviral proteins which are protease, everse transcriptase and endonuclease. The method is characterized by the consecutive expression and processing of retroviral genes by the stepwise cultivation of hosts transformed with a vector constructed to carry retroviral gene fragments comprising at least a protease gene and one or more of the other genes coding for retroviral proteins. The retroviral proteins of this invention are used as specific reagents for the diagnosis of retroviral disease, e.g., AIDS, malignant tumors and so forth, also may be used as the basis for research and development of antiviral agents and a vaccine against the above infectious diseases, and for genetic engineering.

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