Protease-resistant thrombomodulin analogs

Details Protease-resistant thrombomodulin analogs Protease-resistant thrombomodulin analogs

1995-06-05

1998-10-27

Patterson, Jr., Charles L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514822, 530402, 530412, 530419, 530380, A61K 3800, A61K 3816, C07K 1400

Patent

active

058278249

ABSTRACT:
The present invention relates to the single-chain thrombomodulin ("TM") and analogs thereof that are not susceptible to cleavage by proteases and retain the biological activity of thrombomodulin, as well as methods of use in, for example, antithrombotic therapy. Novel proteins, nucleic acid gene sequences, pharmaceuticals and methods of inhibiting thrombotic activity are disclosed.

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