Protease-resistant thrombomodulin analogs

Details Protease-resistant thrombomodulin analogs Protease-resistant thrombomodulin analogs

1995-06-05

1999-01-26

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 696, 4352402, 4352523, 4353201, 536 231, 536 235, C12P 2106, C12P 2104, C12N 1500, C07H 2104

Patent

active

058637605

ABSTRACT:
The present invention relates to the single-chain thrombomodulin ("TM") and analogs thereof that are not susceptible to cleavage by proteases and retain the biological activity of thrombomodulin, as well as methods of use in, for example, antithrombotic therapy. Novel proteins, nucleic acid gene sequences, pharmaceuticals and methods of inhibiting thrombotic activity are disclosed.

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