Protease-resistant modified SEB and vaccine containing the same

Details Protease-resistant modified SEB and vaccine containing the same Protease-resistant modified SEB and vaccine containing the same

2011-05-24

2011-05-24

Zeman, Robert A (Department: 1645)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

C424S237100, C530S350000

Reexamination Certificate

active

07947290

ABSTRACT:
A modified Staphylococcal enterotoxin B (SEB) having resistance to a protease and a reduced toxicity and a vaccine comprising said modified SEB are provided. A modified SEB which has an amino acid sequence as set forth in SEQ ID NO: 1 wherein each of the lysine at 97-position and the lysine at 98-position are substituted with any other amino acid, or a derivative thereof and a vaccine comprising said modified SEB or a derivative thereof.

REFERENCES:
patent: 6180097 (2001-01-01), Terman
patent: 6248329 (2001-06-01), Chandrashekar et al.
patent: 8-500328 (1996-01-01), None
patent: 1055429 (2000-11-01), None
patent: WO93/14634 (1993-08-01), None
patent: 96/36366 (1996-11-01), None
patent: WO96/36366 (1996-11-01), None
patent: 99/40935 (1999-08-01), None
Bowie et al (Science, 1990, 247:1306-1310).
Ellis (Chapter 29 of Vaccines, Plotkin, et al. (eds) WB Saunders, Philadelphia, 1998, especially p. 571, paragraph 2).
Ulrich et al In: R. ZChapter 31 Staphylococcal enterotoxin B and Related Pyrogenic Toxins R.G. In: R. Zatjchuk, Editor, Textbook of military medicine: Medical aspects of chemical and biological warfare Office of the Surgeon General, Department of Army, Washington, DC (1997), pp. 621-630.
Savransky et al 2003 Toxicology Pathology vol. 31 pp. 373-378.
Soos et al 1993 Neuroimmunol. vol. 43 (1-2) Abstract.
A.C. Papageorgiou et al., Crystal structure of the superantigen enterotoxin C2 from Staphylococcus aureus reveals a zinc-binding site, Structure 2(8):769-779, (1995) XP004587900.
Savransky et al., Toxicology Pathology, 31:373-378 (2003).
Soos et al., Neuroimmunol., 43(1-2):39 (1993).
Ulrich et al., Chapter 31 Staphylococcal enterotoxin B and Related Pyrogenic toxins, 621-630, (1997).
Bowie et al., Science, 247:1306-1310 (1990).
Plotkin et al., Chapter 29 of Vaccines, (eds.) WB Sauders, Philadephia, 1998, especially p. 571, paragraph 2.

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