Drug – bio-affecting and body treating compositions – Lymphokine – Interferon
Reexamination Certificate
2011-08-16
2011-08-16
Stoica, Elly-Gerald (Department: 1647)
Drug, bio-affecting and body treating compositions
Lymphokine
Interferon
C424S408000, C435S069510, C530S351000
Reexamination Certificate
active
07998469
ABSTRACT:
Compositions of modified cytokines and uses thereof generated using processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in complex biological settings, are provided. Also provided are modified cytokines formulated for oral delivery and uses thereof to treat diseases and conditions mediated by cytokines.
REFERENCES:
patent: 4044126 (1977-08-01), Cook et al.
patent: 4364923 (1982-12-01), Cook et al.
patent: 4414209 (1983-11-01), Cook et al.
patent: 4518584 (1985-05-01), Mark et al.
patent: 4522811 (1985-06-01), Eppstein et al.
patent: 4588585 (1986-05-01), Mark et al.
patent: 4753795 (1988-06-01), Bell et al.
patent: 4769233 (1988-09-01), Bell et al.
patent: 4793995 (1988-12-01), Bell et al.
patent: 4816396 (1989-03-01), Chang
patent: 4914033 (1990-04-01), Bell et al.
patent: 4937076 (1990-06-01), Lapidus
patent: 5096815 (1992-03-01), Ladner et al.
patent: 5183746 (1993-02-01), Shaked et al.
patent: 5223409 (1993-06-01), Ladner et al.
patent: 5510472 (1996-04-01), Reuel et al.
patent: 5545723 (1996-08-01), Goelz et al.
patent: 5571698 (1996-11-01), Ladner et al.
patent: 5723323 (1998-03-01), Kauffman et al.
patent: 5763239 (1998-06-01), Short et al.
patent: 5798208 (1998-08-01), Crea
patent: 5814485 (1998-09-01), Dorin et al.
patent: 5837500 (1998-11-01), Ladner et al.
patent: 5854049 (1998-12-01), Reed
patent: 5862514 (1999-01-01), Huse et al.
patent: 6001574 (1999-12-01), Short et al.
patent: 6013478 (2000-01-01), Wells et al.
patent: 6057103 (2000-05-01), Short
patent: 6096548 (2000-08-01), Stemmer
patent: 6117679 (2000-09-01), Stemmer
patent: 6127332 (2000-10-01), Goelz et al.
patent: 6132970 (2000-10-01), Stemmer
patent: 6156509 (2000-12-01), Schellenberger
patent: 6165793 (2000-12-01), Stemmer
patent: 6171820 (2001-01-01), Short
patent: 6174673 (2001-01-01), Short et al.
patent: 6180406 (2001-01-01), Stemmer
patent: 6238884 (2001-05-01), Short et al.
patent: 6323006 (2001-11-01), Ferreira et al.
patent: 6472512 (2002-10-01), LaFleur et al.
patent: 6514729 (2003-02-01), Bentzien
patent: 6531122 (2003-03-01), Pedersen et al.
patent: 6572853 (2003-06-01), Schneider-Fresenius
patent: 6608183 (2003-08-01), Cox, III
patent: 6800735 (2004-10-01), Whitty et al.
patent: 6906041 (2005-06-01), Braun
patent: 6962978 (2005-11-01), Pepinsky et al.
patent: 7144574 (2006-12-01), Rasmussen et al.
patent: 7611700 (2009-11-01), Vega et al.
patent: 7647184 (2010-01-01), Vega et al.
patent: 7650243 (2010-01-01), Gantier et al.
patent: 2002/0169290 (2002-11-01), Bornaes et al.
patent: 2003/0129203 (2003-07-01), Vega et al.
patent: 2003/0129584 (2003-07-01), Vega
patent: 2003/0134351 (2003-07-01), Vega et al.
patent: 2003/0175694 (2003-09-01), Vega
patent: 2003/0224404 (2003-12-01), Vega et al.
patent: 2004/0132977 (2004-07-01), Gantier et al.
patent: 2004/0137581 (2004-07-01), Aguinaldo et al.
patent: 2005/0054052 (2005-03-01), Carr et al.
patent: 2005/0054053 (2005-03-01), Aguinaldo et al.
patent: 2005/0202438 (2005-09-01), Gantier et al.
patent: 2006/0020116 (2006-01-01), Gantier et al.
patent: 2006/0020396 (2006-01-01), Gantier et al.
patent: 2006/0094655 (2006-05-01), Guyon et al.
patent: 2006/0195268 (2006-08-01), Vega
patent: 2006/0247170 (2006-11-01), Guyon et al.
patent: 2006/0251619 (2006-11-01), Borrelly et al.
patent: 2007/0224665 (2007-09-01), Gantier et al.
patent: 2007/0249532 (2007-10-01), Guyon et al.
patent: 2007/0254838 (2007-11-01), Gantier et al.
patent: 2007/0265187 (2007-11-01), Vukicevic et al.
patent: 2008/0003202 (2008-01-01), Guyon et al.
patent: 2008/0026993 (2008-01-01), Guyon et al.
patent: 2008/0038224 (2008-02-01), Guyon et al.
patent: 2008/0075672 (2008-03-01), Gantier et al.
patent: 2008/0102115 (2008-05-01), Oyhenart et al.
patent: 2008/0159977 (2008-07-01), Gantier et al.
patent: 2008/0194477 (2008-08-01), Gantier et al.
patent: 2008/0260820 (2008-10-01), Borrelly et al.
patent: 2009/0053147 (2009-02-01), Gantier et al.
patent: 2009/0123974 (2009-05-01), Gantier et al.
patent: 2009/0131318 (2009-05-01), Gantier et al.
patent: 2009/0238789 (2009-09-01), Guyon et al.
patent: 260350 (1992-02-01), None
patent: 1022335 (2000-07-01), None
patent: 95/23813 (1995-09-01), None
patent: 98/13487 (1998-04-01), None
patent: 98/48018 (1998-10-01), None
patent: 99/03887 (1999-01-01), None
patent: 00/68387 (2000-11-01), None
patent: 01/25438 (2001-04-01), None
patent: 01/32711 (2001-05-01), None
patent: 01/32844 (2001-05-01), None
patent: 01/44809 (2001-06-01), None
patent: 01/61344 (2001-08-01), None
patent: 01/86291 (2001-11-01), None
patent: 02/16606 (2002-02-01), None
patent: 02/074783 (2002-09-01), None
patent: 03/023032 (2003-03-01), None
patent: WO 03/018820 (2003-03-01), None
patent: 2004/022593 (2004-03-01), None
patent: 2004/022747 (2004-03-01), None
patent: 2004/031352 (2004-04-01), None
patent: 2004/087753 (2004-10-01), None
patent: 2005/003157 (2005-01-01), None
patent: WO 2006/020580 (2006-02-01), None
patent: 2006/024547 (2006-03-01), None
patent: WO 2006/048777 (2006-05-01), None
patent: WO 2006/120580 (2006-11-01), None
patent: PCT/US07/14219 (2007-06-01), None
patent: WO 2007/110230 (2007-10-01), None
patent: WO 2007/110231 (2007-10-01), None
patent: PCT/GB07/004520 (2007-11-01), None
patent: WO 2007/149406 (2007-12-01), None
patent: WO 2008/065372 (2008-06-01), None
patent: WO 2009/152944 (2009-12-01), None
Karpusas et al.,The crystal structure of human interferonat 2.2-Å resolution, Proc. Natl. Acad. Sci. USA, 11813-11818, 1997.
Bernkop-Schnurch, The use of inhibitory agents to overcome the enzymatic barrier to perorally administered therapeutic peptides and proteins. J. Controlled Release, 52, 1998,1-16.
U.S. Appl. No. 12/082,365, filed Apr. 9, 2008.
U.S. Appl. No. 12/082,389, filed Apr. 9, 2008.
U.S. Appl. No. 12/157,150, filed Jun. 6, 2008.
Office Action, issued Dec. 28, 2007, in connection with related U.S. Appl. No. 11/176,830.
Office Action, issued Dec. 26, 2007, in connection with related U.S. Appl. No. 10/658,834.
U.S. Appl. No. 11/998,387, filed Nov. 28, 2007.
Descamps et al. “Gelatinase B is diabetogenic in acute and chronic pancreatitis by cleaving insulin,” FASEB J, 17:887-889 (2003).
Lee et al. “Serum gelatinase B, TIMP-1 and TIMP-2 levels in multiple sclerosis: A longitudinal clinical and MRI study,” Brain, 122:191-197 (1999).
Beck-Sickinger, G., et al., “Complete L-alanine scan of neuropeptide Y reveals ligands binding to Y1 and Y2 receptors with distinguished conformations,” European Journal of Biochemistry, 223:947-958, (1994).
Biron, C.A., et al., “Natural killer cells in antiviral defenses: function and regulation by innate cytokines,” Annual Review of Immunology, 17:189-220, (1999).
Boger, J., et al., “Surface probability profiles. A heuristic approach to the selection of synthetic peptide antigens,” Reports of the Sixth International Congress in Immunology, p. 250, (1986).
Briand, L., et al., “Impact of the lysine-188 and aspartic acid-189 inversion on activity of trypsin,” FEBS Letters, 442(1):43-47, (1999).
Dayhoff, M.O., et al., “A model of evolutionary changes in proteins,” Atlas of Protein Sequence and Structure, 5(3):345-352, (1978).
Deng, W.P. and J.A. Nickloff, “Site-directed mutagenesis of virtually any plasmid by eliminating a unique site,” Analytical Biochemistry, 200:81-88, (1992).
Diaz, M.O., et al., “Nomenclature of the human interferon genes,” J. Interferon Cytokine Res., 16:179-180, (1996).
Drittanti, L., et al., “High throughput production, screening and analysis of adeno-associated viral vectors,” Gene Therapy, 7(11):924-929, (2000).
Du, B., et al., “Efficient transduction of human neurons with an adeno-associated virus vector,” Gene Therapy, 3:254-261, (1996).
Feng, D.F., et al., “Aligning amino acid sequences: comparison of commonly used methods,” Journal of Molecular Evolution, 21:112-125, (1985).
Fitch, W.M., “An improved method of testing for evolutionary homology
Drittanti Lila
Gantier Rene
Guyon Thierry
Vega Manuel
HanAll BioPharma Co., Ltd.
Stoica Elly-Gerald
Sughrue & Mion, PLLC
LandOfFree
Protease resistant interferon beta mutants does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Protease resistant interferon beta mutants, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Protease resistant interferon beta mutants will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2792815