Protease nexin-I variants which inhibit elastase

Details Protease nexin-I variants which inhibit elastase Protease nexin-I variants which inhibit elastase

1990-06-21

1993-02-16

Wehmar, Elizabeth C.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435218, C12N 948, C12N 966

Patent

active

051870894

ABSTRACT:
One or more amino acid residues within the reactive site region of protease nexin-I are altered in order to create analogs or variants or protease nexin-I. These analogs have substantially different protease specificities as well as different effects on regulating the activity of proteolytic enzymes which enzymes have substantial effects on a number of different physiological functions. Formulations containing the protease nexin-I variants and methods for administering these formulations to obtain desirable therapeutic results are disclosed.

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Scott et al., J. Biol. Chem. (1983) 58:10439-10444.
Eaton et al., J. Biol. Chem. (1984) 259(10):6241-6247.

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