Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1992-08-03
1995-10-10
Schwartz, Richard A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
424 9464, A61K 3855, A61K 3857
Patent
active
054570905
ABSTRACT:
One or more amino acid residues within the reactive site region of protease nexin-I are altered in order to create analogs or variants of protease nexin-I. These analogs have substantially different protease specificities as well as different effects on regulating the activity of proteolytic enzymes which enzymes have substantial effects on a number of different physiological functions. Formulations containing the protease nexin-I variants and methods for administering these formulations to obtain desirable therapeutic results are disclosed.
REFERENCES:
patent: 5187089 (1993-02-01), Scott et al.
Konrad, Chapter 14 Biological Barriers to Protein Delivery Aldus et al. Ed. Plenum Press, New York N.Y.
Ferrado et al. Chpt 1 Protein Pharmacokinetics & Metabolism Ed. Ferraiolo et al. Plenum Press New York N.Y.
Websters Dictionary 1984 Houghton Mifflin Co. Boston, Mass.
Dorland's Illustrated Medical Dictionary 1981 Sauders Press Philadelphia, Pa.
Sommer et al. Biochem 26 (20) pp. 6407-6410 (1987).
Courtney et al. Nature 313 pp. 149-151 (1985).
Farell et al. Biochem. J. 245 pp. 543-550 (1987).
Lehninger, A. L., Biochemistry Second Edition, Worth Publishers, Inc., (1975) pp. 72-75.
McGrogan et al., "Molecular cloning and the expression of two forms of human protease nexin I" Bio/Technology (1988) 6:172-177.
Baker et al., "Protease nexin I structure and potential functions" The Pharmacology and Toxicology of Proteins, UCLA Symposia, Alan R. Liss, Inc. Series V. 65:307-323.
Courtney et al., "Synthesis in Escherichia coli of alpha-antitrypsin variants of therapeutic potential for emphysema and thrombosis" Nature (1985) 313:149-151.
Bieth, J. G. "Pathophysiological interpretation of kinetic constants of protease inhibitors" Bull. Euro. Physiopath. Resp. (1980) 16(Suppl.):183-195.
Scott et al., "Protease nexin" J. Biol. Chem. (1985) 260(11):7029-7034.
Scott et al., "Purification of protease nexin" J. Biol. Chem. (1983) 58:10439-10444.
Eaton et al., "Purification of human fibroblast urokinase proenzyme and analysis of its regulation by protease and protease nexin" J. Biol. Chem. (1984) 259(10):6241-6247.
Golini Fred
McGrogan Michael
Scott Randy W.
Bozicevic Karl
Francis Carol L.
INCYTE Pharamaceuticals, Inc.
Schmickel D.
Schwartz Richard A.
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