Protease inhibitors

Details Protease inhibitors Protease inhibitors

1999-06-11

2000-05-02

Stockton, Laura L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514312, 514337, 514347, 514407, 514445, 514522, 514533, 514529, 5462841, 546293, 546153, 5483701, 549 65, 549461, 558389, 560 13, A61K 31343, C07D30791

Patent

active

060573627

ABSTRACT:
The present invention provides compounds which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease-hypercalcemia of malignancy; and metabolic bone disease, comprising inhibiting said bone loss or excessive cartilage or matrix degradation by administering to a patient in need thereof a compound of the present invention.

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