Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1981-04-01
1982-09-07
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
2601125R, A61K 3700, C07C10352
Patent
active
043483860
ABSTRACT:
An acidic protease inhibitor obtained by allowing a compound of ##STR1## wherein X and Y are L-leucine or L-valine, or its salt, to react with an aluminum compound in a medium containing water and/or an alcohol, and further continuing the reaction after adjusting the pH of the system within a range of 4.5 to 7. The protease can stay long in stomach, have an action to protect ulcerated areas and retain the antiulcer effect for a long period of time.
REFERENCES:
Holm, et al., "Inhibition of Gastric Peptic Activity", pp. 119-121, 1976.
Berstad, et al., "Experience wtih Antipeptic Agents", pp. 121-123, 1979.
Svendsen, et al., Gastric Ulcer Theraphy with a Pepsin Inactivating, pp. 929-932, 1979.
Kameno Yoshito
Koide Ten
Kojima Shin-ichi
Ogino Shigeo
Tsuchiya Toshiro
Phillips Delbert R.
Sumitomo Chemical Company Limited
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