Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-07-04
2006-07-04
Coleman, Brenda (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S211030, C514S217030, C514S217050, C514S217060, C514S217070, C514S217080, C514S217090, C514S217100, C514S217110, C540S525000, C540S596000, C540S597000, C540S598000, C540S599000, C540S601000, C540S602000, C540S603000, C540S604000
Reexamination Certificate
active
07071184
ABSTRACT:
The present invention provides C1-6alkyl-4-amino-azepan-3-one protease inhibitors and pharmaceutically acceptable salts, hydrates and solvates thereof which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, novel intermediates of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease; and parasitic diseases, including malaria, by administering to a patient in need thereof one or more compounds of the present invention.
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Cummings Maxwell D.
Marquis, Jr. Robert W.
Veber Daniel F.
Yamashita Dennis S.
Coleman Brenda
Hall Linda E.
Kinzig Charles M.
SmithKline Beecham Corporation
Venetianer Stephen A.
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