Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-04-02
1999-10-05
Prouty, Rebecca E.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 691, 4352523, 43525233, 4352551, 4352552, 435440, 530324, 536 231, 536 235, C12P 2106, C12N 120, A61K 3800, C07H 2102
Patent
active
059622660
ABSTRACT:
Analogues of the Kunitz Protease Inhibitor (KPI) domain of amyloid precursor protein bind to and inhibit activity of serine proteases, including kallikrein, plasmin and coagulation factors such as factors VIIa, IXa, Xa, XIa, and XIIa. Pharmaceutical compositions containing the KPI analogues, along with methods for using such compositions, are useful for ameliorating and treating clinical conditions associated with increased serine protease activity, such as blood loss related to cardiopulmonary bypass surgery. Nucleic acid sequences encoding these analogues and systems for expression of the peptides of the invention are provided.
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Damm Deborah
Garrick Brett L.
Lesikar David D.
McFadden Kathleen
White R. Tyler
Prouty Rebecca E.
Scios Inc.
Slobodyansky Elizabeth
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