Protease inhibitor conjugates and antibodies useful in...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

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C435S007500, C436S546000, C530S388900, C530S405000, C544S316000

Reexamination Certificate

active

10669831

ABSTRACT:
Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for HIV protease inhibitors. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group common to all HIV protease inhibitors, e.g., saquinavir, nelfinavir, indinavir, amprenavir, ritonavir, lopinavir, and atazanavir.

REFERENCES:
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patent: 2003/0100088 (2003-05-01), Sigler et al.
patent: 1207394 (2002-05-01), None
patent: 2773994 (1999-07-01), None
patent: WO 03/075010 (2003-09-01), None
Valdez et al. “Response to immunization with recall and neoantigens after prolonged administration of an HIV-1 protease inhibitor-containing regimen.” AIDS 2000, vol. 14., No. 1, pp. 1-21.
Wiltshire et al. “Chromatographic and Immunochemical Approaches to the Analysis of the HIV Protease Inhibitor Saquinavir in Plasma”. Analytical Biochemistry 2000, 281, pp. 105-114.
Akeb et al. “Quantification of plasma and intracellular levels of the HIV protease inhibitor ritonavir by competitive ELISA”, Journal of Immunological Methods 263 (2002) 1-9.

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