Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-04-04
1996-08-13
Dentz, Bernard
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514307, 514419, 514485, 514542, 544355, 546146, 546169, 548492, 560 32, 560 39, 564 56, 564153, C07D21548, C07C27120, A61K 3147
Patent
active
055456405
ABSTRACT:
Disclosed herein are compounds which inhibit human immunodeficiency virus (HIV) protease activity and inhibit HIV replication in human cells. Thus, the compounds are indicated for the treatment of HIV infections. The compounds can be represented by the formula ##STR1## wherein X is a terminal group, for example, an aryloxycarbonyl, an alkanoyl or an arylalkyl carbamoyl; A is absent or an amino acid or a derived amino acid; either R.sup.1 or R.sup.2 is hydrogen while the other is alkyl or R.sup.1 and R.sup.2 are joined to form a cyclohexane; Q is hydrogen, hydroxy, halo or lower alkoxy; and Y is a terminal group, for example, an alkylamino, alkoxy or an optionally substituted anilino.
Beaulieu Pierre L.
Guse Ingrid
Bio-Mega/Boehringer Ingeleheim Research Inc.
Dentz Bernard
Devlin M-E. M.
Raymond R. P.
Stempel A. R.
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