Protease for activating clotting factor VII

Details Protease for activating clotting factor VII Protease for activating clotting factor VII

2005-06-28

2005-06-28

Weber, Jon (Department: 1653)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C435S013000, C435S007100, C514S002600, C514S012200, C514S021800, C530S350000, C530S381000

Reexamination Certificate

active

06911334

ABSTRACT:
A protease for activating the blood clotting factor VII is described, wherein the protease is inhibited by the presence of aprotinin and is increased in its activity by calcium ions and/or heparin or heparin-related substances, and wherein in SDS-PAGE, on subsequent staining in the non-reduced state, the protease has one or more brands in the molecular weight range from 50 to 75 kDa, and in the reduced state, the protease has a band at 40 to 55 kDa and one or more bands in the molecular weight range from 10 to 35 kDa. The proenzyme of this protease is also characterized. Further, a process for obtaining this protease and its use in hemorrhage prophylaxis or hemostasis is described. Moreover, a test system for the qualitative and quantitative detection of a protease which activates the blood clotting factor VII is described.

REFERENCES:
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patent: WO 91/01497 (1991-02-01), None
patent: WO 96/10638 (1996-04-01), None
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