Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1994-08-12
1996-12-31
Jacobson, Dian C.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
435221, 4353201, 536 232, C12N 121, C12N 954, C12N 1557, C12N 1575
Patent
active
055893830
ABSTRACT:
A Bacillus cell contains a mutation in the epr gene resulting in inhibition of the production by the cell of the proteolytically active epr gene product; the cell may further contain mutations in the genes encoding proteolytically active residual protease I (bpr) and proteolytically active residual protease II (RP-II).
REFERENCES:
patent: 4828994 (1989-05-01), Fahnestock et al.
Band et al., Construction and Properties of an Intracellular Serine Protease Mutant of Bacillus subtilis, Journal of Bacteriology 169:444-446, 1987.
Beall et al., Cloning and Characterization of Bacillus subtilis Homologs of Escherichia coli Cell Division Genes ftsZ and ftsA, Journal of Bacteriology 170:4855-4864, 1988.
Bruckner and Doi, Characterization of a Gene for a Minor Extracellular Protease from Bacillus subtilis, Abstract, No. 13, Fourth Conference on Genetics and Biotechnology of Bacilli, San Diego, CA, 1987.
Bruckner et al., Characterization of a Gene for a Minor Extracellular Protease of Bacillus subtilis Produced During Sporulation, Abstract, No. 49, Program of the Tenth Int'l Spores Conference, Woods Hole, MA, 1988.
Fahnestock and Fisher, Protease-Deficient Bacillus subtilis Host Strains for Production of Staphylococcal Protein A, Applied and Environmental Microbiology 53:379-384, 1987.
Ferrari et al., Effect of Stage O Sporulation Mutations on Subtilisin Expression, Journal of Bacteriology, 166:173:173-179, 1986.
Kawamura and Doi, Construction of a Bacillus subtilis Double Mutant Deficient in Extracellular Alkaline and Neutral Proteases, J. Bacteriol. 160:442-444, 1984.
Koide et al., Cloning and Sequencing of the Major Intracellular Serine Protease Gene of Bacillus subtilis, J. Bacteriol. 167:110-116, 1986.
Ohmura et al., A Bacillus subtilis Secretion Vector System Derived from the B. subtilis A-Amylase Promoter and Signal Sequence Region, and Secretion, J. Biochem. 95:87-93, 1984.
Palva et al., Secretion of Interferon by Bacillus subtilis, Gene 22:229-235, 1983.
Roitsch and Hageman, Bacillopeptidase F: Two Forms of A Glycoprotein Serine Protase From Bacillus subtilis J. of Bacteriology 155:152, 1983.
Sloma et al., Gene Encoding a Minor Extracellular Protease in Bacillus subtilis, J. of Bacteriology 170-5557-5563, 1988.
Sloma et al., Bacillopeptidase F of Bacillus subtilis: Purification of the Protein and Cloning of the Gene J. of Bacteriology 172:1470-1477, 1990.
Smith et al., Characterization of Signal-Sequence-Coding Regions Selected From the Bacillus subtilis Chromosome, Gene 70:351-361, 1988.
Srivastava and Aronson, Isolation and Characterization of a Unique Protease from Sporulating Cells of Bacillus subtilis, Arch Microbiol 129:227-232, 1981.
Stahl and Ferrari, Replacement of the Bacillus subtilis Subtilisin Structural Gene with an In Vitro-Derived Deletion Mutation, J. of Bacteriology 158:411-418, 1984.
Yang et al., Cloning of the Neutral Protease Gene of Bacillus subtilis and the Use of the Cloned Gene to Create an In Vitro-Derived Deletion Mutation, J. of Bacteriology, 160:15-21, 1984.
Bruckner et al., Multiple Active Forms of a Novel Serine Protease From Bacillus subtilis, Mol. Gen Genet 221:486-490, 1990.
Rufo et al., Isolation and Characterization of a Novel Extracellular Metalloprotease From Bacillus subtilis, Journal of Bacteriology 172:1019-1023, 1990.
Sloma et al., Bacillopeptidase F of Bacillus subtilis: Purification of the Protein and Cloning of the Gene, Errata, J. Bact. 172:5520-5521, Sep. 1990.
Sloma et al., Gene Encoding a Novel Extracellular Metalloprotease in Bacillus subtilis, J. of Bacteriology 172:1024-1029, 1990.
Wang et al., Construction of Bacillus subtilis Mutant-Deficient in Three Extracellular Proteases, J. Gen. Appl. Microbiol. 35:487-492, 1989.
Wu et al., Cloning Genetic Organization, and Characterization of a Structural Gene Encoding Bacillopeptidase F From Bacillus subtilis, The Journal of Biological Chemistry 265:6845-6850, 1990.
Pero Janice
Rudolph Cathy F.
Rufo, Jr. Gerald A.
Sloma Alan
Sullivan Barbara J.
Jacobson Dian C.
Omnigene, Inc.
LandOfFree
Protease deletion does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Protease deletion, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Protease deletion will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1141542