Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Reexamination Certificate
2005-09-20
2005-09-20
Achutamurthy, Ponnathapura (Department: 1652)
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
C424S193100, C435S188000, C435S220000, C435S221000, C435S222000, C510S300000, C510S392000
Reexamination Certificate
active
06946128
ABSTRACT:
The present disclosure relates to subtilisin protease conjugate comprising a protease moiety and one or more addition moieties. Each addition moiety is covalently attached to an epitope protection position of the protease moiety. The protease conjugates have decreased immunogenicity relative to a parent protease. The present disclosure further relates to cleaning and personal care compositions comprising the protease conjugates.
REFERENCES:
patent: 4179337 (1979-12-01), Davis et al.
patent: 4248786 (1981-02-01), Batz
patent: 4266031 (1981-05-01), Tang et al.
patent: 4556554 (1985-12-01), Calvo
patent: 4732863 (1988-03-01), Tomasi et al.
patent: 4760025 (1988-07-01), Estell
patent: 4980288 (1990-12-01), Bryan
patent: 5122614 (1992-06-01), Zalipsky
patent: 5133968 (1992-07-01), Nakayama et al.
patent: 5208158 (1993-05-01), Bech et al.
patent: 5230891 (1993-07-01), Nakayama
patent: 5324653 (1994-06-01), Van Eekelen et al.
patent: 5324844 (1994-06-01), Zalipsky
patent: 5340735 (1994-08-01), Christianson et al.
patent: 5414135 (1995-05-01), Snow et al.
patent: 5446090 (1995-08-01), Harris
patent: 5482849 (1996-01-01), Branner et al.
patent: 5543302 (1996-08-01), Boguslawski et al.
patent: 5631217 (1997-05-01), Branner et al.
patent: 5631322 (1997-05-01), Veronese et al.
patent: 5658871 (1997-08-01), Batenburg et al.
patent: 5766898 (1998-06-01), Loevborg
patent: 5766987 (1998-06-01), Mitchell et al.
patent: 5856451 (1999-01-01), Olsen et al.
patent: 5972339 (1999-10-01), Walker
patent: 5985264 (1999-11-01), Metzger et al.
patent: 6060546 (2000-05-01), Powell et al.
patent: 6218165 (2001-04-01), Estell et al.
patent: 6300116 (2001-10-01), van der Osten et al.
patent: 2 206 826 (1973-08-01), None
patent: 0 130 756 (1985-01-01), None
patent: 0 215 662 (1987-03-01), None
patent: 0 260 105 (1988-03-01), None
patent: 0 398 539 (1990-11-01), None
patent: 0 405 901 (1991-01-01), None
patent: 0 471 125 (1992-12-01), None
patent: 0 516 200 (1992-12-01), None
patent: 0 584 876 (1994-03-01), None
patent: 0 251 446 (1994-12-01), None
patent: 0 816 381 (1998-01-01), None
patent: WO 87/04461 (1987-07-01), None
patent: WO 87/05050 (1987-08-01), None
patent: WO 88/07578 (1988-10-01), None
patent: WO 88/08028 (1988-10-01), None
patent: WO 88/08033 (1988-10-01), None
patent: WO 88/08164 (1988-10-01), None
patent: WO 88/08165 (1988-10-01), None
patent: WO 91/00345 (1991-01-01), None
patent: WO 92/10755 (1992-06-01), None
patent: WO 93/15189 (1993-08-01), None
patent: WO 93/19731 (1993-10-01), None
patent: WO 93/19732 (1993-10-01), None
patent: WO 93/25667 (1993-12-01), None
patent: WO 94/04193 (1994-03-01), None
patent: WO 95/07991 (1995-03-01), None
patent: WO 95/10615 (1995-04-01), None
patent: WO 95/20039 (1995-07-01), None
patent: WO 95/29979 (1995-11-01), None
patent: WO 95/30010 (1995-11-01), None
patent: WO 96/09396 (1996-03-01), None
patent: WO 96/16177 (1996-05-01), None
patent: WO 96/17929 (1996-06-01), None
patent: WO 96/40791 (1996-12-01), None
patent: WO 96/40792 (1996-12-01), None
patent: WO 97/07770 (1997-03-01), None
patent: WO 97/24421 (1997-07-01), None
patent: WO 97/24427 (1997-07-01), None
patent: WO 97/30148 (1997-08-01), None
patent: WO 97/37007 (1997-10-01), None
patent: WO 98/23732 (1998-06-01), None
patent: WO 98/30682 (1998-07-01), None
patent: WO 98/35026 (1998-08-01), None
patent: WO 99/04489 (1999-01-01), None
patent: WO 99/33868 (1999-07-01), None
patent: WO 99/37324 (1999-07-01), None
patent: WO 99/40936 (1999-08-01), None
patent: WO 99/41369 (1999-08-01), None
patent: WO 99/42097 (1999-08-01), None
patent: WO 99/44635 (1999-09-01), None
patent: WO 99/45904 (1999-09-01), None
patent: WO 99/48918 (1999-09-01), None
patent: WO 99/49056 (1999-09-01), None
patent: WO 00/09707 (2000-02-01), None
patent: WO 00/28007 (2000-05-01), None
patent: WO 00/37658 (2000-06-01), None
Davis, F. F., et al., 1990, “Reduction of immunogenicity and extension of circulating half-life of peptides and proteins”, Advances in Parenteral Science, vol. 4, pp. 831-864.
Abuchowski, A., et al., 1981, “Soluble polymer-enzyme adducts”, in Enzymes Drugs, Rutgers University Press, New Brunswick, New Jersey, Chapter 13, pp. 367-383.
Masunaga, T., et al., 1993, “The protease as a cleansing agent and its stabilization by chemical modification”, Journal of the Japanese Society of Cosmetic Chemistry, vol. 27, pp. 276-288.
Arlian, L.G. et al., “Antigenic and Allergenic Characteristics of the Enzyms Alcalase and Savinase by Crossed Immunoelectrophoresis and Crossed Radioimmunoelectrophoresis”, Int. Arch Allergy Appl Immunol, vol. 91, pp. 278-284 (1990).
Abuchowski, A. et al., “Cancer Therapy with Chemically Modified Enzymes. I. Antitumor Properties of Polyethylene Glycol-Asparaginase Conjugates”, Cancer Biochem Biophys, vol. 7, pp. 175-186 (1984).
Bungy Poor Fard, G.A. et al., T Cell Epitopes of the Major Fraction of Rye Grass Lolium Perenne (lol p I) Defined Using Overlapping Peptides in Vitro and In Vivo. I. Isoallergen Clone 1A, Clin Exp Immunol, vol. 94, pp. 111-116 (1993).
Caliceti, P. et al., “Active Site Protection of Proteolytic Enzymes by Poly(ethylene glycol) Surface Modification” Journal of Bioactive and Compatible Polymers, vol. 8, Jan., 1993, pp. 41-50.
Delgado, C. et al., “The Uses and Properties of PEG-Linked Proteins”, Critical Review in Therapeutic Drug Carrier Systems, 9(3,4) (1992), pp. 249-304.
Favre, C. et al., “Epitope Mapping of Recombinant Human Gamma Interferon Using Monoclonal Antibodies”, Molecular Immunology, vol. 26, No. 1, pp. 17-25 (1989).
Francis, G.E. et al., “PEG-Modified Proteins”, Stability of Protein Pharmaceuticals, Part B: in Vivo Pathways of Degradation and Strategies for Protein Stabilization, edited by Ahern, T.J. and Mannin, M.C., Plenum Press (1992), pp. 235-263.
Hopp. T.P. et al., “Prediction of Protein Antigenic Determinants from Amino Acid Sequences”, Proc. Natl Acad Sci, vol. 78, No. 6, pp. 3824-3828 (1981).
Katre, N.V., “The Conjugation of Proteins with Polyethylene Glycol and Other Polymers”, Advanced Drug Delivery Reviews, 10 (1993), pp. 92-114.
Khan, S.A. et al., “Polyethylene Glycol-modified Subtilisin Forms Microparticulate Suspensions in Organice Solvents”, Enzyme Microb. Technology, vol. 14, Feb. (1992), pp. 96-100.
Masakatzu Ohta et al., “Preparation of a Dextran-Protease Conjugate and its Application to Cosmetic Use”, Kanebo, Ltd., Cosmetics Laboratory Japan,Cosmetics and Toiletries,vol. 111, pp. 79-88, 1996.
Monfardini, C. et al., “A Branched Monoethoxy Poly(ethylene glycol) for Protein Modification”, Bioconjugate Chemistry, vol. 6, No. 1, (1995), pp. 62-69.
Nishimura, H. et al., “Improved Modification of Yeast Uricase with Polyethylene Glycol, Accompanied with Non-immunoreactivity Towards Anti-Uricase Serum and High Enzymic Activity”, ENZYME 26 (1981), pp. 49-53.
Nucci, M.L. et al., “The Therapeutic Value of Poly(ethylene glycol)-modified Proteins”, Advanced Drug Delivery Reviews, 6 (1991), pp. 133-149.
Reay, P.A. et al., “Use of Global Amino Acid Replacements to Define the Requirements for MHC Binding and T Cell Recognition of Moth Cytochrome c (93-103)”, Journal of Immunology, vol. 152, No. 8, pp. 3946-3957 (1994).
Ritz, H.L. et al., “Respiratory and Immunological Responses of Guinea Pigs to Enzyme-Containing Detergents: A Comparison of Intratracheal and Inhalation Modes of Exposure”, Fundamental and Applied Toxicology, vol. 21, pp. 31-37 (1993).
Robinson, M.K. et al., “Specific Antibody Responses to Subtilisin Carlsberg (Alcalase) in Mice: Development of an Intranasal Exposure Model”, Fundamental and Applied Toxicology, vol. 24, pp. 15-24 (1996).
Savoca, K.V. et al., “Preparation of a Non-immunogenic Agrinase by the Covalent Attachment of Polyethylene Glycol”, Biochemica et Biophysica Acta, 578 (1979), pp. 47-53.
Siezen et al., “Homology Modelling and Protein Engineeri
Correa Paul Elliott
Rubingh Donn Nelton
Weisgerber David John
Achutamurthy Ponnathapura
Frieko Laura L.
Kendall Dara M.
Moore William W.
Peebles Brent M.
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