Protease and related nucleic acid compounds

Details Protease and related nucleic acid compounds Protease and related nucleic acid compounds

1997-07-09

1998-11-24

Jacobson, Dian C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

435212, 435219, 435226, C12N 948, C12N 964, C12N 914, C12Q 137

Patent

active

058405097

ABSTRACT:
The present invention provides for a novel ICE related protease and nucleic acids coding same. The present invention also provides a method to isolate an ICE related protease and related DNA compounds encoding this protease. The present invention further comprises a method using said protease to screen for inhibitors of apoptosis. Additionally, the invention further comprises a method of using said inhibitors of apoptosis in the treatment in human patients with the acquired disease states of brain ischemia, stroke, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), head trauma, or other neurodegenerative disorders.

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D'Mello et al., Proc. Natl. Acad Sci USA, 90, 10989-10993, (1993).
Kuida et al., Science, 267, 2000-2003, (1995).
Cotman et al., Molecular Neurobiology, 10, 19-45 (1995).
Raff et al., Science, 262, 695-700, (1993).
Wood et al., Neuron, 11, 621-632, (1993).

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