Protease-activated receptor PAR4 (ZCHEMR2)

Details Protease-activated receptor PAR4 (ZCHEMR2) Protease-activated receptor PAR4 (ZCHEMR2)

2006-10-17

2006-10-17

Ulm, John (Department: 1649)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S252300, C435S320100, C536S023500

Reexamination Certificate

active

07122342

ABSTRACT:
The present invention relates to polynucleotide and polypeptide molecules for PAR4, a novel member of the protease-activated receptor family. The polypeptides, and polynucleotides encoding them, mediate biological responses and/or cellular signaling in response to proteases. Protease cleavage of PAR4 exposes a PAR4 extracellular amino terminal portion that serves as a ligand for the PAR4 receptor. PAR4 may be used as a target in drug screening, and further used to identify proteinaceous or non-proteinaceous PAR4 agonists and antagonists. The present invention also includes antibodies to the PAR4 polypeptides.

REFERENCES:
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