Protamine-reactive IGM antibodies

Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals

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435 792, 435974, 435975, 436548, 436808, 530329, 530330, 530358, 5303879, 530852, 530863, G01N 3353

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active

058720120

ABSTRACT:
The present invention is directed to protamine-reactive, IgM antibodies, and their uses in prognosis, diagnosis, and therapy. In a specific embodiment, the invention relates to low affinity binding, protamine-reactive serum IgM antibodies. In particular, such antibodies can recognize a sequence comprising four arginyl residues, including a triplet, within a six amino acid residue sequence. Such antibodies may be natural antibodies (i.e., not induced). A low affinity subset of serum protamine-reactive IgM antibodies may be assayed for prognosis or diagnosis of AIDS. Such antibodies are detectable in sera of normal subjects and HIV-infected individuals who subsequently exhibit a significant period of latency, but are absent or deficient in sera of individuals diagnosed with AIDS and sera of HIV infected individuals, who though asymptomatic at the time of the sampling, proceed to AIDS within a relatively short time. The invention provides methods and diagnostic kits for the detection and/or measurement of the low affinity subset of protamine-reactive serum IgM antibodies, for the prognosis and diagnosis of AIDS and other immune system abnormalities.

REFERENCES:
patent: 4699877 (1987-10-01), Cline et al.
Rodman et al, "Naturally Occurring Antibodies Reactive with Sperm Proteins: Apparent Deficiency in Aids Sera", Science, vol. 228, No. 4704 (7 Jun. 1985) pp. 1211-1215.
Rodman et al, "Reactivity of Natural LgM Antibodies with Sperm Head Surface Proteins -Use of ELISA to Characterize the Reaction", Journal of Immunological Methods, vol. 94, (1986) pp. 105-111.
Rodman et al, "Protamine-Reactive Natural LgM Antibodies in Human Sera", Journal of Experimental Medicine, vol. 167 No. 3 (Mar. 1, 1988), pp. 1228-1246.
Chemical Abstract 107 (15): 132233 "Monoclonal Antibodies to Human protamine" in Hybridoma 1987, 6(3) 313-20.
Chemical Abstract 109 (1): 4921, "Detection of the Major Epitopes of Human Protamine Pl Recognized by Rabbit and Mouse Antibodies" in Mol. Immunol 25(4) 403-10, 1988.
Roitt et al, Immunology (C.V. Mosby Company St. Louis) 1985, pp. 6.5-66.
Biological Abstract 78: 11446.
Rodman et al, Clin. Immunol. Immunopathol. 571 430-440 (1990).
Rodman et al, Proc. Natl. Acad. Sci., USA, 90: 7719-7723 (1993).
Morcos et al, "Reactivated Movement of Decondensed Rat Sperm Models and a Description of their Ultrastructure," J. of Exp. Zoology 270: 388-398 (1994).
Neits et al, "Direct Measurement of Antibody Affinity Distribution by Hapten-Inhibition Enzyme Immunoassay," Mol. Immunol. 21(6):537-543 (1984).
Benner et al., 1982, Immunology Today, 9:243-249.
Chow et al., 1981, Int. J. Cancer 27:459-469.
Jerne, Niels K., 1955, Bacteriology 41:849-857.
Kolk and Samuel, Biochim. Biophys. Acta 393:307-319 (1975).
Rodham et al., J. Cell Biol. 80:605-620 (1979).
Samuel, Immunol. Comm. 9(3):283-288 (1980).
Rodman et al., J. Cell Sci. 53:227-244 (1982).
Rodman et al., Gamete Res. 8:129-147 (1983).
Rodman et al., Exp. Cell Res. 150:269-281 (1984).
Ammer et al., Biol. Chim. Hoppe-Seyler 367:515-522 (1986).
McKay et al., Eur. J. Biochem. 156:5-8 (1986).
Pruslin et al., Gamete Res. 18:179-190 (1987).
Hald et al., J. Repro. Fert. 10:15-26 (1987).
Stanker et al., Hybridoma 6(3):293-303 (1987).
Roux et al., J. Repro. Fert. 82:35-42 (1988).
Dighiero et al., J. Immunol 134:765-771 (1985).
Tongio et al., Tissue Antigens 26:271-285 (1985).
Cohen and Cooke, Immun. Today 7(12): 363-364 (1986).
Gottlieb et al., N. Engl. J. Med. 305:1425-1431 (1981).
Masur et al., N. Engl. J. Med. 305:1431-1438 (1981).
Barre-Sinoussi et al., Science 220:868-871 (1983).
Gallo et al., Science 224:500-503 (1984).
Feorino et al., Science 225:69-72 (1984).
Levy et al., Science 225:840-842 (1984).
Klatzman et al., Nature 312:767-768 (1984).
Dalgleish et al., Nature 312:763-766 (1984).
Goedert et al., Lancet ii:711-716 (1984).
Mavligit et al., J. Am. Med. Assoc. 251:237-247 (1984).
Ranki et al., Cancer Res. 45:4616S-4618S (1985).
McDougal et al., Science 231:382-385 (1986).
Maddon et al., Cell 47:333-348 (1986).
Ratnam et al., Aust. N.Z.J. Med. 15:757-760 (1986).
Darrow et al., Am. J. Pub. Hlth. 77:479-483 (1987).
Kingsley et al., Lancet ii:345-348 (1987).
Adams et al., Clin. Immunol. Immunopath. 46:442-449 (1988).
Morrison et al., Proc. Natl. Acad. Sci. USA 81:6851-6855 (1984).
Takeda et al., Nature 314:452-454 (1985).
Pruslin et al., J. Immunol. Meth. 94:99-103 (1986).
DeLange et al., Proc. Natl. Acad. Sci. USA 69:882-884 (1972).
Shoenfeld et al., Arthritis Rheum. 30:169-175 (1987).
Dyrberg and Oldstone, J. Exp. Med. 164:1344-1349 (1986).
Geysen et al., Science 235:1184-1190 (1987).

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