Prostatic growth factor

Details Prostatic growth factor Prostatic growth factor

2007-10-16

2007-10-16

Andres, Janet L. (Department: 1649)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S320100, C435S325000, C536S023500, C536S024100, C536S024310

Reexamination Certificate

active

10270377

ABSTRACT:
The present invention relates to human PGF polypeptides and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques, and antibodies and antagonist/inhibitors against such polypeptides. Also provided are methods of using such polypeptides therapeutically for treating prostate cancer, to promote tissue regeneration and to facilitate wound healing. Also provided is a diagnostic assay to detect prostate cancer and benign prostatic hyperplasia.

REFERENCES:
patent: 4931548 (1990-06-01), Lucas et al.
patent: 5141905 (1992-08-01), Rosen et al.
patent: 5168051 (1992-12-01), Derrynck et al.
patent: 5221620 (1993-06-01), Purchio et al.
patent: 5223408 (1993-06-01), Goeddel et al.
patent: 5332669 (1994-07-01), Deuel
patent: 5366875 (1994-11-01), Wozney et al.
patent: 5994102 (1999-11-01), Hudson et al.
patent: 6680372 (2004-01-01), Lee et al.
patent: 7-250688 (1995-10-01), None
patent: 7-258293 (1995-10-01), None
patent: WO-97/00958 (1997-01-01), None
patent: WO-97/36926 (1997-10-01), None
patent: WO-98/11224 (1998-03-01), None
U.S. Appl. No. 09/912,293, Rosen et al., not published, pp. 1-75 (pp. 1 and 2 partially redacted); portion of Table 2; Seq ID Nos.54368 and 54742.
U.S. Appl. No. 09/912,292, Rosen et al., not published, pp. 1-75 (pp. 1 & 2 partially redacted); portion of Table 2; and Seq ID Nos.11029 and 11037.
Abaza et al.,J. Protein Chem., 11(5):433-444 (1992).
Anscher et al.,The New England Journal of Medicine, 328(22):1592-1598 (1993).
Bauskin et al., “The propeptide of macrophage inhibitory cytokine (MIC-1), a TGF-.beta. superfamily member, acts as a quality control determinant for correctly folded MIC-1”EMBO J. 19(10):2212-2220 (2000).
Bootcov et al., “MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-.beta. superfamily,”Proc. Natl. Acad. Sci. USA94:11514-11519 (Oct. 1997).
Bottner et al., “Characterization of the rat, mouse, and human genes of growth/differentiation factor-15/macrophage inhibiting cytokine-1 (GDF-15/MIC-1).”Gene, 237:105-111 (1999).
Buckhaults et al., “Secreted and cell surface genes expressed in benign and malignant colorectal tumors,”Cancer Res., 61:6996-7001 (Oct. 1, 2001).
Coleman et al.,Research in Immunology, 145(1):33-36 (1992).
Fairlie et al., “Epitope mapping of the transforming growth factor-.beta. superfamily protein, macrophage inhibitory cytokine-1 (MIC-1): Identification of at least five distinct epitope specificities,”Biochem., 40:65-73 (2001).
Fairlie et al., “MIC-1 is a novel TGF-.beta. superfamily cytokine associated with macrophage activation,”J. Leuk. Bio., 65:2-5 (Jan. 1999).
Fairlie et al., “The propeptide of the transforming growth factor-.beta. superfamily member, macrophage inhibitory cytokine-1 (MIC-1), is a multifunctional domain that can facilitate protein folding and secretion,”J. Biol. Chem., 276(20):16911-16918 (May 18, 2000).
Genbank Accession No. NM—004864, “Homo sapiensprostate differentiation factor (PLAB), mRNA,” May 26, 2001.
Genbank Accession No. NP—004855, “Prostate differentiation factor; PTGF-beta [Homo sapiens],” May 26, 2001.
Geneseq Accession No: R07335 (1991).
George et al., Macromolecular Sequencing & Synth., 127-149 (1988).
Kingsley, “The TGF.beta. superfamily: new members, new receptors, and genetic tests of function in different organisms,”Gene&Development, 8:133-146 (1994).
Lawton et al., “Identification of a novel member of the TGF-beta superfamily highly expressed in human placenta,”Gene, 203:17-26 (1997).
Lederman et al.,Molecular Immunology, 28:1171-1181 (1991).
Li et al., “Placental transforming growth factor-.beta. is a downstream mediator of the growth arrest and apoptotic response of tumor cells to DNA damage and p53 overexpression,”J. Biol. Chem., 275 (26), 20127-20135 (2000).
Li et al.,PNAS, 77:3211-3214 (1980).
Lin et al.,Cell, 68:775-785 (1992).
Massague, “The TGF-.beta. Family of Growth and Differentiation Factors,”Cell, 49:437-438 (1987).
Mikayama et al.,PNAS, 90:10056-10060 (1993).
Ngo et al. in The Protein Folding Problem and Tertiary Structure Prediction, Merz et al., (ed), Birkhauser, Boston, MA, pp. 433 and 492-495 (1994).
Paralkar et al., “Cloning and characterization of a novel member of the transforming growth factor-.beta./bone morphogenetic protein family”,J. Biol. Chem., 273 (22), 13760-13767 (1998).
Welsh et al., “Analysis of gene expression identifies candidate markers and pharmacological targets in prostate cancer,”Cancer Res., 61:5974-5978 (Aug. 15, 2001).
Yokoyama-Kobayashi et al., “Human cDNA encoding a novel TGF-.beta. superfamily protein highly expressed in placenta,”J. Biochem., 122:622-626 (1997).

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