Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal
Patent
1997-02-11
2000-08-08
Clark, Deborah J.
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
Transgenic nonhuman animal
800 21, 800 23, 800 25, 435325, 435354, 4353201, 536 231, 536 235, 536 241, C12N 500, C12N 510, C12N 518, C07H 2104
Patent
active
061004448
ABSTRACT:
The non-coding regulatory sequences of the prostate specific antigen (PSA) are described. Non-human transgenic animals are also provided which express human PSA, which is non-naturally occurring in non-human animals.
REFERENCES:
patent: 5416017 (1995-05-01), Burton et al.
patent: 5648478 (1997-07-01), Henderson
Lundwall A. (Biochem. Biophys. Res. Commu. vol. 161 (3) 1989, 1151-1159).
Grisolano et. al. (Proc. Natl. Aca. Sci. Sep. 1994, vol. 91 (19) 8989-93). Abstract only.
Lee et al. (Anticancer Res. Aug. 7, 1996, 16:1805-1812).
Wagner et al. Genetic Engineering: Principles and Methods. 1988, vol. 10, p221-246, (p. 221 and p. 238 Only).
Houdebine L.-M. J. Biotechnol. 34, 1994, 269-287.
Wall R. J. Theriogenology, 45, 57-68, 1996.
Augee, M. L. Platypus and Echidnas. The Royal Zoological Society of New South Wales, New South Wales. 1992, Section of Reproduction.
Hew et al. US 5,545,808, 1996, Aug. (First page and Column 4 only).
Wight et al. Transgenic mice: a decade of progress in technology and research. Mutation Research, vol. 307, pp. 429-440, Jun. 1, 1994.
Gordon et al., "Regulation of Thy-1 Gene Expression in Transgenic Mice", Cell, vol. 50, 445-452, Jul. 31, 1987.
Eades-Perner et al., "Mice Transgenic for the Human Carcinoembyronic Antigen Gene Maintain Its Spatiotemporal Expression Pattern", Cancer Research, 54, 4169-4176, Aug. 1, 1994.
Schaffner et al., "Transgenic Mice Carrying A PSArasT24 Hybrid Gene Develop Salivary Gland and Gastrointestinal Tract Neoplasms", Laboratory Investigation, vol. 72, No. 3, p. 283, 1995.
Greenberg et al., "Prostate cancer in a transgenic mouse", Proc. Natl. Acad. Sci., vol. 92, pp. 3439-3443, Apr. 1995.
Wei et al., "Expression of human prostate-specific antigen (PSA) in a mouse tumor cell line reduces tumorigenicity and elicits PSA-specific cytotoxic T lymphocytes", Cancer Immunol. Immunother, (1996) 42:362-368.
Schuur et al., "Prostate-specific Antigen Expression Is Regulated by an Upstream Enhancer", The Journal of Biological Chemistry, vol. 271, No. 12, pp. 7043-7051, Mar. 22, 1996.
Frelinger et al., "Targeted CTL-mediated immunity for prostate cancer: development of human PSA-expressing transgenic mice", AACR Meeting, Apr. 20-24, 1996 (Abstract).
Frelinger et al., "Targeted CTL-Mediated Immunity for Prostate Cancer: Development of Human PSA-Expressing Transgenic Mice", 1st Annual Meeting of the Pepper Centers, May 13-15, 1996 (Abstract).
Wei et al., "Development of human PSA-expressing transgenic mice to investigate targeted CTL-mediated immunity for prostate cancer", ASBMB/ASIP/AAI Joint Meeting, Jun. 2-6, 1996 (Abstract).
Frelinger et al., "Targeted CTL-Mediated Immunity for Prostate Cancer: Development of Human PSA-Expressing Transgenic Mice", First International Conference of Immunology and Aging, Jun. 16-19, 1996 (Abstract).
Cleutjens et al., Journ. Biolog. Chem., 271:6379-6388 (1996).
Cleutjens et al., Mol. Endocrinol., 11:148-161 (1997).
Lundwall et al., FEBS, 214:317-322 (1987).
Riegman et al., Biochem. & Biophys. Res. Com., 159:95-102 (1989).
Riegman et al., FEBS, 247:123-126 (1989).
Riegman et al., Mol. Endocrinol., 5:1921-1930 (1991).
Shulz et al., Nucl. Acids Res., 16:6226 (1988).
Barth Richard K.
Frelinger John G.
Wei Chungwen
Clark Deborah J.
University of Rochester Medical Center
LandOfFree
Prostate specific regulatory nucleic acid sequences and transgen does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Prostate specific regulatory nucleic acid sequences and transgen, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Prostate specific regulatory nucleic acid sequences and transgen will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1151658