Prostate-specific kallikrein

Details Prostate-specific kallikrein Prostate-specific kallikrein

1998-06-22

1999-07-13

Lau, Kawai

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

435212, A61K 3848, C12N 948

Patent

active

059223219

ABSTRACT:
The present invention provides a human prostate-specific kallikrein (HPSK) and polynucleotides which identify and encode HPSK. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HPSK and a method for producing HPSK. The invention also provides for agonists, antibodies, or antagonists specifically binding HPSK, and their use, in the prevention and treatment of diseases associated with expression of HPSK. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HPSK for the treatment of diseases associated with the expression of HPSK. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HPSK.

REFERENCES:
Bridon, D.P. et al., "Structural Comparison of Prostate-Specific Antigen and Human Glandular Kallikrein Using Molecular Modeling" Urology 45:801-806.
Christensson, A. et al., "Enzymatic activity of prostate-specific antigen and its reactions with extracellular serine proteinase inhibitors" Eur. J. Biochem 194:755-763 (1990).
Cramer S. D. et al., "Prostate specific antigen cleaves parathyroid hormone-related protein in the PTH-like domain: inactivation of PTHrP-stimulated cAMP accumulation in mouse osteoblasts" J. Urol. 156:526-531 (1996).
Evans B.A. et al., "Structure and chromosomal localization of the human renal kallikrein gene" Biochemistry 27:3124-3129 (1988) (Accession GI 186651).
Fukushima, D. et al., "Nucleoside sequence of cloned cDNA for human pancreatic kallikrein" Biochemistry 24:8037-8043 (1985).
Henttu P. et al., "Prostate-specific antigen and human glandular kallikrein: two kallikreins of the human prostate" Ann. Med. 26:157-164 (1994).
Lundwall, A., "Characterization of the gene for prostate-specific antigen, a human glandular kallikrein" Biochem Biophys Res Commun 161:1151-1159 (1989) (Accession GI 190553).
Perelygina, et al., (Direct Submission), GenBank Sequence Database Accession GI 871814), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
Riegman, P.H. et al., "Characterization of the human kallikrein locus" Genomics 14:6-11 (1992).
EMBL Sequence Database, Accession No. AA551449, Sep. 1997.
EMBL Sequence Database, Accession No. AA533140, Jul. 1997.

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