Prostate specific enhancer polynucleotides and methods of use th

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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536 241, 4353201, 435325, 435455, A61K 4800, C07H 2104, C12N 500, C12N 1500

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active

061367923

ABSTRACT:
The invention provides a human prostate-specific transcriptional regulatory sequence, polynucleotide comprising such regulatory regions, toxin gene constructs wherein a toxin gene is expressed under the transcriptional control of a human prostate-specific transcriptional regulatory sequence, and methods for treating prostate disease using such toxin gene constructs.

REFERENCES:
patent: 4683202 (1987-07-01), Mullis
patent: 5648478 (1997-07-01), Henderson
patent: 5698443 (1997-12-01), Henderson et al.
Adair et al., "Targeted homologous recombination at the endogenous adenine phosphoribosyltransferase locus in Chinese hamster cells" Proc. Natl. Acad. Sci. (USA) (1989) 86:4574-4578.
Allan et al., "Synergism betwen Steroid Response and Promoter Elements during Cell-free Transcription" J. Biol. Chem. (1991) 266:5905-5910.
An et al., "Expression of bacterial .beta.-galactosidase in animal cells" Mol. Cell. Biol. (1982) 2:1628-1632.
Bagchi et al., "Steroid Hormone-Dependent Interaction of Human Progesterone Receptor with its Target Enhancer Element" Mol. Endocrinol. (1988) 2:1221-1229.
Beato, "Gene Regulation by Steroid Hormones" Cell (1989) 56:335-344.
Behr et al., "Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine-coated DNA" Proc. Natl. Acad. Sci. (USA) (1989) 86:6982-6986.
Behringer et al., "Dwarf mice produced by genetic ablation of growth hormone-expressing cells" Genes & Dev. (1988) 2:453-461.
Bradshaw et al., "A Steroid Response Element can Function in the Absence of a Distal Promoter" Mol. Endocrinol. (1988) 2:1286-1993.
Brinster et al., "Introns increase transcriptional efficiency in transgenic mice" Proc. Natl. Acad. Sci. (USA) (1988) 85:836-840.
Capecchi, "Altering the Genome by Homologous Recombination" Science (1989) 244:1288-1292.
Chaudhary et al., "Pseudomonas exotoxin contains a specific sequence at the carboxyl terminus that is required for cytotoxicity" Proc. Natl. Acad. Sci. (USA) (1990) 87:308-312.
Cornetta et al., "No Retroviremia or Pathology in Long-Term Follow-Up Monkeys Exposed to a Murine Amphotropic Retrovirus" Hum. Gene Ther. (1991) 2:215-219.
Dean et al., "Effects of Exogenous Amines on Mammalian Cells, with Particular Reference to Membrane Flow" Biochem. J. (1984) 217:27-40.
Dignam et al., "Accurate Transcription Initiation by RNA Polymerase II in a Soluble Extract From Isolated Mammalian Nuclei" Nucl. Acids Res. (1983) 11:1475-1489.
Eckert et al., "DNA Polymerase Fidelity and the Polymerase Chain Reaction" PCR Methods and Applications (1991) 1:17-24.
Felgner et al., "Lipofection: A Highly Efficient, Lipid-Mediated DNA-Transfection Procedure" Natl. Acad. Sci. USA (1987) 84:7413-7417.
Frankel et al., "Selection and Characterization of Ricin Toxin A-Chain Mutations in Saccharomyces cerevisiae" Mol. Cell. Biol. (1989) 9:415-420.
Gao et al., "A Novel Cationic Liposome Reagent For Efficient Transfection of Mammalian Cells" Biochem. Biophys. Res. Commun. (1991) 179:280-285.
Ghadzizadeh et al., "Prostatic Origin of Metastases: Immunoperoxidase Localization of Prostate-Specific Antigen" Urol. Int. (1984) 39:9-12.
Gotoh et al., "New strategy of toxic gene therrapy for human prostate cancer cells" J. Urol. (1995) 153:308A (abstract No. 320).
Hamdy et al., "Circulating Prostate Specific Antigen-positive Cells Correlate with Metastatic Prostate Cancer" Br. J . Urol. (1992) 69:392-396.
Ho et al., "Interactions Of Antigen-Sensitized Liposomes With Immobilized Antibody: A Homogenous Solid-Phase Immunoliposome Assay" J. Immunol. (1985) 134:4035-4040.
Hogan et al., Manipulating the Mouse Embryo: A Laboratory Manual, (1988) Cold Spring Harbor Laboratory. The title page and table of contents are included herewith.
Horoszewicz et al., "LNCaP Model of Human Prostatic Carcinoma" Cancer Res. (1983) 43:1809-1818.
Hwang et al., "Functional Domains of Pseudomonas Exotoxin Identified by Deletion Analysis of the gene Expressed in E. Coli" Cell (1987) 48:129-136.
Innis et al., eds., PCR Protocols: A Guide to Methods and Applications, (1990) Academic Press. The title page and table of contents are included herewith.
Johnson et al., "Targeting of Nonexpressed Genes in Embryonic Stem Cells via Homologous Recombination" Science (1989) 245:1234-1236.
Kolberg, "Gene-Transfer Virus Contaminant Linked to Monkey's Cancer" J. NIH Res. (1922) 4:43-44.
Kovarik et al., "Analysis of the Tissue-specific Promoter of the MUCI Gene" J. Biol. Chem. (1993) 268:9917-9926.
Lamb et al., "Nucleotide Sequence of Cloned cDNA Coding for Preproricin" Eur. J. Biochem (1985) 148:265-270.
Lemaigre et al., "Liver-specific Factor Binding to the Liver Promoter of a 6-Phosphofructo-2-kinase/Fructose-2, 6-bisphosphatase Gene" J. Biol. Chem. (1993) 268:19896-19905.
Litzinger et al., "Phosphatidylethanolamine liposomes: Drug Delivery, Gene Transfer and Immunodiagnostic Applications" Biochem. Biophys. Acta (1992) 1113:201-227.
Lundwall et al., "Molecular Cloning of Human Prostate Specific Antigen cDNA" FEBS Lett. (1987) 214:317-322.
Mannino et al., "Liposome Mediated Gene Transfer" Biotechniques (1988) 6:682-690.
Mansour et al., "Disruption of the Proto-oncogene int-2 in Mouse Embryo-Derived Stem Cells: a General Strategy for Targeting Mutations to Non-Selectable Genes" Nature (1988) 336:348-352.
Mattila et al., "Fidelity of DNA Synthesis by the Thermococcus litoralis DNA Polymerase --an Extremely Heat Stable Enzyme with Proofreading Activity" Nucleic Acids Res. (1991) 19:4967-4973.
Maxwell et al., "Cloning, Sequence Determination, and Expression in Transfected Cells of the Coding Sequence for the tox 176 Attenuated Diphtheria Toxin A Chain" Mol. Cell. Biol. (1987) 7:1576-1579.
Messing et al., "P.sub.O Promoter Directs Expression of Reporter and Toxin Genes to Schwann Cells of Transgenic Mice" Neuron (1992) 8:507-520.
Meyer et al., "Steroid hormone receptors compete for factors that mediate their enhancer function" Cell (1989) 57:433-442.
Miller et al., "Gene Transfer by Retrovirus Vectors Occurs Only in Cells that are Actively Replicating at the Time of Infection" Mol. Cell. Biol. (1990) 10:4239-4242.
Mitchell et al., "Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins" Science (1989) 245:371-378.
Mocellini et al., "Finasteride (MK-906) in the Treatment of Benign Prostatic Hyperphlasia" The Prostate (1993) 22:291-299.
Moss, Vaccinia virus: A tool for research and vaccine development Science (1991) 252:1662-1667.
Nabel et al., "Immunotherapy of malignancy by in vivo gene transfer into tumors" Human Gene Therapy (1992) 3:399-410. Note: pp. 400-401 are missing from the original document.
Nawaz et al., "Identification of Novel Steroid-Response Elements" Gene Expr. (1992) 2:39-47.
Nitsch et al., "The Distal Enhancer Implicated in the Developmental Regulation of the Tyrosine Amino Transferase Gene Is Bound by Liver-Specific and Ubiquitous Factors" Mol. Cell. Biol. (1993) 13:4494-4504.
Ozono et al., "The Vitamin D-responsive Element in the Human Osteocalcin Gene" J. Biol. Chem. (1990) 265:21881-21888.
Palmiter et al., "Cell Lineage Ablation in Transgenic Mice by Cell-Specific Expression of a Toxic Gene" Cell (1987) 50:435-443.
Papsidero et al., "Prostate Antigen: A Marker for Human Prostate Epithelial Cells" J. Natl. Cancer Inst. (1981) 66:37-42.
Pearson et al., "Improved Tools for Biological Sequence Comparison" Proc. Natl. Acad. Sci. USA (1988) 85:2444-2448.
Piatak et al., "Expression of Soluble and Fully Functional Ricin A Chain in Escherichia coli is Temperature-Sensitive" J. Biol. Chem. (1988) 263:4837-4843.
Redding et al., "Prostate Carcinoma Tumor Size in Rats Decrease after Administration of Antagonists of Luteinizing Hormore-releasing Hormone" Proc. Natl. Acad. Sci. (1982) 79:1273-1276.
Rhodes et al., "A Tissue-specific Enhancer Confers Pit-1-dependent Morphogen Inducibility and Autoregulation on the pit-1 Gene" Genes Dev. (1993) 7:913-932.
Reiger et al., eds., Glossary of Genetics and Gytogenetics, Classical and Molecular, 4th Ed., Springer-Verlag, Berlin, (1976) pp. 381-383.
Riegman et al., "Characterization of the Prostate-Specific Antigen Gene:

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