Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1995-06-07
1999-06-15
Horlick, Kenneth R.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
435219, 530350, C12N 964
Patent
active
059121580
ABSTRACT:
Prostate specific antigen (PSA) is a protein that can form complexes with proteinase inhibitors such as .alpha..sub.1 -antichymotrypsin. The invention is characterized in that the measurement of the ratio of free PSA to PSA bound to proteinase inhibitors (free PSA:PSA-proteinase inhibitor complex) is useful in the diagnosis of patients with prostate cancer.
REFERENCES:
patent: 4446122 (1984-05-01), Chu et al.
patent: 5599677 (1997-02-01), Dowell et al.
patent: 5599686 (1997-02-01), DeFeo-Jones et al.
Stenman, U.-H. (1990). "Some Examples of the Effect of Immunoassay Design on Clinical Utility", Clinical Chemistry 36(6):1244-1245.
Schaller, J. et al. (1987). "Isolation, characterization and amino-acid sequence of .gamma.-seminoprotein, a glycoprotein from human seminal plasma", Eur. J. Biochem. 170:111-120.
Christensson et al., Eur. J. Biochem. 194, 755-763 (Dec. 1990).
Stenman et al., Cancer Res. 51, 222-226 (1991).
Lilja et al., Clin. Chem. 37(9), 1618-1625 (1991).
DIALOG Information Service, File 351, WPIL, Accession No. 007662133 (WAKP) Wako Pure Chem. Ind. KK, "Determining antigen specific to human prostate gland . . . ", Japanese 63/215967 and 880908 8842 (Basic).
New York Academy of Sciences; N.Y. Annals, vol. 417 (1983) Chu et al., "Circulating Antibody to Prostate Antigen in Patients with Prostatic Cancer," (pp. 383-389).
Patent Abstracts of Japan, vol. 11, No. 233, P600, Abstract of Japanese Patent 62-46263, publ. 1987 Feb. 28; Chugai Pharmaceut. Co. Ltd.
Watt et al. (1986). Proc. Natl. Acad. Sci. USA 83:3166.
Lilja, H. (1985). J. Clin. Invest. 76:1899.
Lilja Hans
Stenman Ulf-H.ang.kan
LandOfFree
Prostate specific antigen (PSA)-proteinase inhibitor complexes does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Prostate specific antigen (PSA)-proteinase inhibitor complexes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Prostate specific antigen (PSA)-proteinase inhibitor complexes will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-402060