Prostate-specific antigen probes for optical imaging

Details Prostate-specific antigen probes for optical imaging Prostate-specific antigen probes for optical imaging

2008-05-13

2008-05-13

Kosar, Andrew D. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S002600, C514S006900, C530S300000, C530S327000, C530S333000

Reexamination Certificate

active

07371728

ABSTRACT:
This invention provides a novel probe, which contains a prostate peptide substrate. The probe can be used as a prostate diagnostic agent for optical imaging. An 11 amino acid peptide substrate is synthesized for specific prostate-specific antigen (PSA). This protected graft copolymer (PGC) consists of a poly-L-lysine (PL) backbone and methoxypoly(ethylene glycol) (MPEG). Two terminals of peptide substrate are bound to poly-L-lysine and Cy5.5 fluorochrome. This probe will be used as a NIR (near-infrared fluorescence) probe for optical imaging.

REFERENCES:
patent: WO 00/04391 (2000-01-01), None

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