Prostate-derived mitogen

Details Prostate-derived mitogen Prostate-derived mitogen

1989-05-24

1994-07-26

Hill, Jr,, Robert J.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

530399, 530827, 530854, C12N 500, A61K 3736

Patent

active

053326695

ABSTRACT:
A prostate-derived growth factor is disclosed which has a mol. wt. of about 28 kDa, an NH.sub.2 -terminal sequence substantially identical to the NH.sub.2 -terminal sequence of the 6 kDa mature rat EGF, potent mitogenic activity against NRK cells without additional carboxy terminal processing to the mature 6 kDa EGF molecular species, cross-reacts with antisera against rat EGF and its mitogenic activity is blocked by anti-EGF receptor antisera.

REFERENCES:
Lawson et al., in The Prostatic Cell: Structure and Function, Part A, pp. 325-336, Alan R. Liss, Inc. N.Y., 1981.
Story et al., J. Urol. 130, 175-179 (1983).
Jacobs et al., Urol. 16, 428-491 (1980).
Simpson et al., Endocrinology 117, 1615-1620 (1985).
Harper et al., Nature 279, 160-162 (1979).
Harper et al., J. Neurochem. 34, 893-903 (1980).
Nishi et al., Biochem. Biophys. Res. Commun. 132, 1103-9 (1985).
Tackett et al., J. Urology, 133, 45-48 (1985).
Kris, et al., Biotechnology, Feb. 1985, pp. 135-140.
Gray et al., Nature 303, 722-725 (1983).
Scott et al., Science 221, 236-240 (1983).

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