Prostate cancer drug screenings

Details Prostate cancer drug screenings Prostate cancer drug screenings

1996-08-06

1998-07-21

Feisee, Lila

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435 71, 435 723, 4353201, 435326, 536 241, C12H 120, G01H 3353, C07H 2104

Patent

active

057834350

ABSTRACT:
Screening of compounds for activity toward inhibition of prostate cancer cell proliferation is provided. A cell line is employed which can be used in conventional equipment for determining activity of compounds, where the cell line uses a marker whose expression is responsive to therapeutically active compounds.

REFERENCES:
Culig, Z. et al. 1994. Cancer Research, 54: 5474-5478.
Pang, S. et al 1995. Human Gene Therapy, 6: 1417-1426.
Decensi, A. et al. 1994. The Prostate, 24: 17-23.
de Wet et al., "Firefly luciferase gene: structure and expression in mammalian cells" Molecular and Cellular Biology (1987) 7(2):725-737.
Pang et al., "Prostate tissue specificity of the prostate-specific antigen promoter isolated from a patient with prostate cancer" Human Gene Therapy (1995) 6:1417-1426.
Schuur et al., "Prostate-specific antigen expression is regulated by an upstream enhancer" Journal of Biological Chemistry (1996) 27l(12):7043-7051.

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