Prostate cancer drug screening using hKLK2 enhancer

Details Prostate cancer drug screening using hKLK2 enhancer Prostate cancer drug screening using hKLK2 enhancer

1997-08-04

2000-04-18

Eyler, Yvonne

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435 6, 435 8, 436 63, 436 64, C12N 120, C12Q 168, C12Q 166, G01N 3348

Patent

active

060514175

ABSTRACT:
Screening of compounds for activity toward inhibition of prostate cancer cell proliferation is provided. A cell line containing an expression construct comprising a transciptional initiation region of a prostate specific enhancer from a human glandular kallikrein (hKLK2) gene is employed which can be used in conventional equipment for determining activity of compounds, where the cell line uses a marker whose expression is responsive to therapeutically active compounds.

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