Prostate-associated serine protease

Details Prostate-associated serine protease Prostate-associated serine protease

1998-02-17

2000-06-13

Johnson, Nancy A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 232, 536 235, 536 2431, 435 6, 435 691, 4352523, 4353201, C07H 2104, C12N 1511, C12N 1563, C12N 121, C12Q 168

Patent

active

060751363

ABSTRACT:
The invention provides a human prostate-associated serine protease (PRASP) and polynucleotides which identify and encode PRASP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of PRASP.

REFERENCES:
patent: 5840871 (1998-11-01), Hillman
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Riegman, P.H.J. et al., "Characterization of the Prostate-Specific Antigen Gene: A Novel Human Kallikrein-Like Gene", Bioch. Biophys. Res. Commun., 159: 95-102 (1989).
Brawer, M.K. and P.H. Lange, "Prostate-Specific Antigen in Management of Prostatic Carcinoma", Urology, 33: 11-16 (1989).
Chen, Z.L. et al., (Direct Submission Dec. 9, 1996), GenBank Sequence Database (Accession 1020091), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, (GI 1020091).
Chen, Z.L. et al., (Direct Submission Dec. 9, 1996), GenBank Sequence Database (Accession D30785), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, (GI 1648847; GI 1020091).
Riegman, P.H. et al., (Direct Submission Jan. 8, 1995), GenBank Sequence Database (Accession 511857), national Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, (GI 511857).
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Takayama T K et al: "Characterization of the precursor of prostate-specific antigen Activation by trypsin and by human glandular kallikrein" Journal of Biological Chemistry, vol. 272, No. 34, Aug. 22, 1997 (1997-08-20), pp. 21582-21588, XP002100950.
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Genebank Accession No:AA412318 May 18, 1997.
1994-1995 Promega Catalog, p. 167.
Lehniger, A. "Biochemistry" Worth Publishers, NY p. 962, 1975.
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