Prostate-associated kallikrein

Details Prostate-associated kallikrein Prostate-associated kallikrein

1997-01-29

1998-11-24

Huff, Sheela

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 691, 4353201, 435 7, C07H 2104, C12P 2106, C12N 1500, C12N 1509

Patent

active

058408711

ABSTRACT:
The present invention provides a human prostate-associated kallikrein (HPAK) and polynucleotides which identify and encode HPAK. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HPAK and a method for producing HPAK. The invention also provides for antibodies or antagonists specifically binding HPAK, and their use, in the prevention and treatment of diseases associated with expression of HPAK. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HPAK for the treatment of diseases associated with the expression of HPAK. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HPAK.

REFERENCES:
Fukushima et al 1985 Biochemistry 24: 8037-8043.
Evans et al Biochemistry 27:3124-3129 (1988).
Baker et al (1985) DNA 4(6):445-450.
Angermann et al 1989 Biochem J 262:787-793.
Henttu, P. et al., "Prostate-specific antigen and human glandular kallikrein: two kallikreins of the human prostate.", Ann. Med. (1994) 26:157-164.
Cramer, S.D. et al., "Prostate specific antigen cleaves parathyroid hormone-related protein in the PTH-like domain: inactivation of PTHrP-stimulated cAMP accumulation in mouse osteoblasts.", J. Urol. (1996) 156:526-531.
Riegman, P.H. et al., "Characterization of the human kallikrein locus.", Genomics (1992) 14:6-11.
Bridon, D.P. et al., "Structural comparison of prostate-specific antigena and human glandular kallikrein using molecular modeling.", Urology (1995) 45:801-806.
Fahnestock, M. et al., "Characterization of kallikrein cDNAs from the African rodent Mastomys.", DNA Cell Biol. (1994) 13:293-300.
Christensson, A. et al., "Enzymatic activity of prostate-specific antigen and its reactions with extracellular serine proteinase inhibitors.", Eur. J. Biochem. (1990) 194:755-763.

Affiliated with

Also associated with

Rating

Prostate-associated kallikrein does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Prostate-associated kallikrein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Prostate-associated kallikrein will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1703643