Prostanoic acid derivatives and their preparation

Details Prostanoic acid derivatives and their preparation Prostanoic acid derivatives and their preparation

1982-09-01

1984-12-18

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

2603457P, 2603458P, 2603473, 2603474, 260456R, 260464, 2603405P, 2603407, 2603409P, 260410, 542426, 556441, 424278, 424305, 424317, 560118, 560121, 560231, 562500, 562503, C07C17700, A61K 31557

Patent

active

044890923

ABSTRACT:
Prostanoic acid derivatives of the formula ##STR1## wherein R.sub.1 is an acid, ester, amide or hydroxyalkylene group; R.sub.2 and R.sub.3 are H or alkyl; R.sub.4 and R.sub.5 are both CH.sub.3 or one is Cl and the other is CH.sub.3 ; A is CH.sub.2 CH.sub.2 or --CH.dbd.CH; B is CH.sub.2 CH.sub.2, trans-CH.dbd.CH, --C.tbd.C-- or ##STR2## W is free or functionally modified hydroxyalkylene or carbonyl; Z is free or functionally modified hydroxymethylene or carbonyl; X Y is either ##STR3## or, when Z is free or functionally modified hydroxymethylene, ##STR4## or, when Z is free or functionally modified carbonyl, --CH.dbd.CH--, R.sub.12 being H, CH.sub.3, CH or free or functionally modified hydroxy; and physiologically acceptable salts thereof when R.sub.1 is an acid group, possess pharmacological activity, including abortion triggering activity.

REFERENCES:
patent: 3932479 (1976-01-01), Floyd
patent: 4220798 (1980-09-01), Scolastico

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