Prostaglandins E and anti ulcers containing same

Details Prostaglandins E and anti ulcers containing same Prostaglandins E and anti ulcers containing same

1995-03-10

1999-03-23

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514573, 560121, 562503, C07C17700, A61K 31557

Patent

active

058860347

ABSTRACT:
The novel 13,14-dihydro-15-keto prostaglandins E of the invention have remarkable preventive effects against ulcers. Further, the novel 13,14-dihydro-15-keto-prostaglandins E of the invention have an advatage that they have none of side effects which prostaglandin E intrinsically has, or can remarakably reduce such effects of the prostaglandin E. Therefore, the novel 13, 14-dihydro-15-keto prostaglandins E of the invention are effective for animal and human use for treatment and prevention of ulcers, such as duodenal ulcer and gastric ulcer.

REFERENCES:
patent: 3836578 (1974-09-01), Samuelsson
patent: 5166174 (1992-11-01), Ueno
Erik Anggard, "The Biological Activities of Three Metabolites of Prostaglandin.sub.1 " Acta Physiol. Scand. (1966) 66: 509-510.

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