Prostaglandins

Details Prostaglandins Prostaglandins

1989-03-06

1991-04-09

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514469, 514529, 514530, 514542, 514501, 514562, 514563, 514564, 514565, 514573, 514580, 514585, 514588, 514595, 514598, 514599, 514516, 546269, 546305, 546306, 546309, 549463, C07C17700, A61K 31557

Patent

active

050065394

ABSTRACT:
Novel compounds have a formula (I) ##STR1## wherein ##STR2## represents a bicyclo [2,2,1] hept-2Z-ene, bicyclo [2,2,1]heptane, 7-oxa-bicyclo [2,2,1] hept-2Z-ene, 7-oxa-bicyclo [2,2,1] heptane, bicyclo [2,2,2] oct-2Z-ene or bicyclo [2,2,2] octane substituted at the 5-position by the group R.sup.1 and at the 6-position by the group ANR.sup.2 R, a 6,6-dimethyl-bicyclo [3,1,1] heptane substituted at the 2-position by the group R.sup.1 and at the 3-position by the group ANR.sup.2 R or at the 2-position by the group ANR.sup.2 R and at the 3-position by the group R.sup.1, a cyclohex-1-ene or cyclohexane substituted at the 4-position by the group R.sup.1 and at the 5-position by the group ANR.sup.2 R or a 1-hydroxyclopentane substituted at the 2-position by the group R.sup.1 and at the 2-position by the group ANR.sup.2 R, R.sup.1 is a 6-carboxyhex-2-enyl group or a modification thereof as defined herein; A is an unbranched or branched aliphatic hydrocarbon group with a chain length between the points of attachment to the divalent cyclic group and to the group NR.sup.2 R of 1 to 5 carbon atoms or such a group substituted by an aromatic group; R.sup.2 is hydrogen, an aliphatic hydrocarbon group, an aromatic group or an aliphatic hydrocarbon group substituted by an aromatic group or groups; and R is a group --CO.NR.sup.3 R.sup.4, --CS.NR.sup.3 R.sup.4, --CNH.NR.sup.3 R.sup.4, --CO.R.sup.4 or --CO.R.sup.4 in which R.sup.3 is hydrogen, an aliphatic hydrocarbon group, an aromatic group or an aliphatic hydrocarbon group substituted by an aromatic group or groups, and R.sup.4 is an aliphatic hydrocarbon group, an aromatic group or an aliphatic hydrocarbon group substituted directly by an aromatic group or groups and/or through an oxygen or sulphur atom either by an aromatic group or by an aliphatic hydrocarbon group substituted directly by an aromatic group or groups. The compounds are of value for use in pharmaceutical compositions particularly in the context of the inhibition of thromboxane activity.

REFERENCES:
patent: 3773795 (1973-11-01), Bagli et al.
patent: 4073933 (1978-02-01), Shimomura et al.
patent: 4143054 (1979-03-01), Sprague
patent: 4187236 (1980-02-01), Sprague
patent: 4228180 (1980-10-01), Sprague
patent: 4239778 (1980-12-01), Venton et al.
patent: 4389413 (1983-06-01), Hamanaka et al.
patent: 4416896 (1983-11-01), Nakane et al.
patent: 4418076 (1983-11-01), Nakane et al.
patent: 4438136 (1984-03-01), Jones et al.
patent: 4456615 (1984-06-01), Nakane et al.
patent: 4463015 (1984-07-01), Haslanyer et al.
patent: 4537904 (1985-08-01), Snitman et al.
patent: 4537981 (1985-08-01), Snitman et al.
patent: 4556675 (1985-12-01), Snitman et al.
patent: 4614825 (1986-09-01), Snitman et al.
Katsube et al, Agr. Biol. Chem. (1972), 36, 1997-2004, "Synthesis of Prostaglandin-F.sub.1 Related Compounds".
Eggelte et al, J. C. S., Perkin (I) (1978), pp. 980-989, "Synthesis of 9,11-Epoxy-9a-homoprostaglandin Analogues".
Ansell, et al, Adv. Prost. Throm. Res. (1980), vol. 6, pp. 485-487, "A Structural Analog of Thromboxane A.sub.2 ".
Ishida et al, Chem. Pharm. Bull (1980), 28, pp. 783-788, "Heterocyclic Prostaglandins III, Synthesis of 10.sub.1 -oxa-11-deoxyprostaglandin-E.sub.2 ".
Shimomura et al, Tet. Letts. (1976), No. 45, pp. 4099-4102, "Synthesis of 9,11-Deoxy-9,11-vinyleno-PGF.sub.2 .alpha.-and its Diastereoisomer . . . ".
Eggelte et al, Recueil, J. Royal Netherlands Chem. Soc. (1977), 96, (10), pp. 271-275, "Synthesis of 9,11-Dideoxy-9a-homoprostaglandins".
Nicolaou et al, Angewandte Chemie (1978), 17, pp. 293-312, "Synthesis and Biological Properties of Prostaglandin Endoperoxides, Thromboxanes and Prostacyclins".
Sprague et al, Adv. Prost. Throm. Res., vol. 6, p. 493, "Stero Controlled Synthesis of 7-oxa bicyclo [2,2,1]heptane Prostaglandin Analogues".

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