Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1997-05-30
1998-07-07
Richter, Johann
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
558413, 564 97, 564 99, A61K 31245, A61K 31135, C07C30902
Patent
active
057769842
ABSTRACT:
The present invention provides a compound of the formula: ##STR1## Such compounds are useful for inhibiting prostaglandin synthesis. Pharmaceutical compositions and methods for inhibiting prostaglandin synthesis are also disclosed.
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Mitchell et al; Cyclooxygenase-2: Regulation and Relevance in Inflammation; Biochemical Pharmacology. vol. 50 No. 10 pp. 1535-1542, 1995.
Battistini et al; Cox-1 and Cox-2: Toward the Develpment of More Selective Nsaids, Drug Use and Perspectives 7(8), (1994) 501-512.
Dewitt et al; The Differential Susceptibility of Prostaglandin Endoperoxide H Synthases-1 and -2 to Nonsteroidal Anti-Inflammatory Drugs: Aspirin Derivatives as Selective Inhibitors; Med Chem Res (1995) 5:325-343.
Dellaria Joseph F.
Gane Todd H.
Abbott Laboratories
Cross Lutz Laura
Richter Johann
Steele Gregory W.
Yang Frank Z.
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