Prostaglandin-lipid formulations

Details Prostaglandin-lipid formulations Prostaglandin-lipid formulations

1988-05-18

1992-01-21

Dixon, Jr., William R.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

4284022, 436829, 264 43, A61K 3722

Patent

active

050826646

ABSTRACT:
A liposome composition and methods for making same are disclosed, such compositions comprise an arachidonic acid metabolite such as a prostaglandin, preferably prostaglandin E.sub.1, a lipid, and a drying protectant such as a saccharide. The liposomes may be loaded with prostaglandin passively, or using a transmembrane concentration gradient, preferably using a transmembrane pH gradient. Using this transmembrane loading technique, trapping efficiencies of 50% to 100% are achieved, and the release rate of the prostaglandin from the liposomes is reduced. The liposome size is maintained after lyophilization and reconstitution.

REFERENCES:
patent: 3993754 (1976-11-01), Rahman et al.
patent: 4145410 (1979-03-01), Sears
patent: 4229360 (1980-10-01), Schneider et al.
patent: 4235871 (1980-11-01), Papahadjopoulos et al.
patent: 4370349 (1983-01-01), Evans et al.
patent: 4493847 (1985-01-01), Mizushima et al.
patent: 4522803 (1985-06-01), Lenk et al.
patent: 4588578 (1986-05-01), Fountain et al.
Bangham et al., "Diffusion of Univalent Ions Across the Lamellae of Swollen Phospholipids", 1965; J. Mol. Biol., 12:238-252.
Batzri et al., "Single Bilayer Liposomes Prepared Without Sonication", 1973; Biochim. Biophys. Acta., 298:1015-1019.
Hoshi et al., "Prostaglandin E, Incorporated in Lipid Microspheres in the Treatment of Peripheral Vascular Diseases and Diabetic Neuropathy", 1986; Drugs Exptl. Clin. Res., XII(8):681.
Mizushima et al., "Prostaglandin E.sub.1 is More Effective, When Incorporated in Lipid Microspheres for Treatment of Peripheral Vascular Diseases in Man", 1983; J. Pharm. Pharmacol. 35:666-667.
Moncada et al., "Prostaglandins, Prostacyclin, and Thromboxane A.sub.2 "; The Pharmacol. Basis of Therapeutics, MacMillan Pub., Inc., NY, pp. 668-676.
Papahadjopoulos et al., "Phospholipid Model Membranes", 1968; Biochim. Biophys. Acta., 135:624-638.
Shulkin et al., "Lyophilized Liposomes: A New Method for Long-Term Vesicular Storage", 1984; J. Microencapsulation, 1(1):73.

Affiliated with

Also associated with

Rating

Prostaglandin-lipid formulations does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Prostaglandin-lipid formulations, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Prostaglandin-lipid formulations will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-114423