Prostaglandin derivatives of the .DELTA.2,4-11-deoxy-PEG series

Details Prostaglandin derivatives of the .DELTA.2,4-11-deoxy-PEG series Prostaglandin derivatives of the .DELTA.2,4-11-deoxy-PEG series

1979-07-05

1981-03-24

Love, Ethel G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

2603407, 2603409P, 560210, 560121, 562503, 424317, A01N 3700, C07C 6974

Patent

active

042580579

ABSTRACT:
The present invention relates to novel prostaglandin derivatives of the formula I ##STR1## which are structurally related to the naturally occurring prostaglandins and in which R.sup.1 denotes (a) hydrogen or a straight-chain or branched, saturated or unsaturated aliphatic or cycloaliphatic hydrocarbon radical having up to ten carbon atoms or (b) a physiologically acceptable metal or NH.sub.4 ion or an ammonium ion which is derived from a primary, secondary or tertiary amine and R.sup.2 denotes a straight-chain, aliphatic hydrocarbon radical having up to six carbon atoms and to a process for their manufacture.
The compounds of the invention are distinguished in particular by gastric acid secretion-inhibiting and ulcer-protective properties.

REFERENCES:
patent: 4061670 (1977-12-01), Floyd, Jr. et al.
patent: 4098815 (1978-07-01), Babej et al.
patent: 4165437 (1979-08-01), Hayashi et al.
Chem. Abstract 91:187085a.

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