Prostaglandin derivatives for the treatment of glaucoma or ocula

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai

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A01K 31557

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active

052965040

ABSTRACT:
The invention relates to ophthalmological compositions for topical treatment of glaucoma or ocular hypertension comprising an effective intraocular pressure reducing amount of a prostaglandin derivative of PGA, PGB, PGD, PGE or PGF, in which the omega chain contains a ring structure, in an ophthalmologically compatible carrier. The invention further relates to the preparation of said compositions and their use for treatment of glaucoma or ocular hypertension.

REFERENCES:
patent: 3956284 (1976-05-01), Hess et al.
patent: 3962312 (1976-06-01), Hayashi et al.
patent: 4011262 (1977-03-01), Hess et al.
patent: 4116988 (1978-09-01), Nelson
patent: 4117119 (1978-09-01), Kurono et al.
patent: 4131738 (1978-12-01), Smith
patent: 4599353 (1986-07-01), Bito
patent: 4820728 (1989-04-01), Collins et al.
patent: 4824857 (1989-04-01), Goh et al.
patent: 4883819 (1989-11-01), Bito
patent: 5001153 (1991-03-01), Ueno et al.
patent: 5057621 (1991-10-01), Cooper et al.
patent: 5151444 (1992-09-01), Ueno et al.
patent: 5166178 (1992-11-01), Ueno
patent: 5194429 (1993-03-01), Ueno
Bill A (1975) "Blood Circulation and fluid dynamics in the eye". Physiol. Rew. 55: 383-417.
Bito L. Z., Draga A., Blanco D. J., Camras C. B. (1983) "Long Term Maintenance of Reduced intraocular Pressure by Daily or Twice Daily Topical Application of Prostaglandins to Cat or Rhesus Monkey Eyes" Invest. Ophthalmol. Vis. Sci. 24: 312-319.
Bito, L. Z., Camras C. B., Gum G. G. and Resul B. (1989), "The Ocular Hypotensive Effects and Side Effects of Prostaglandins on the Eyes of Experimental Animals" Progress in Clinical and Biological Research 312 Ed. L. Z. Bito and Johan Stjernschantz, A. R. Liss, Inc., New York.
Burke et al., "Prostaglandin F.sub.2a Effects on Rabbit IOP Negatively Correlate with Classical PGF.sub.2.alpha. -Receptor Stimulation", Presented at ARVO annual meeting in Florida May 1-6, 1988.
Bundy, Chem Abst. 90:168141d, 1979.
Camras C. B., Bito L. Z. (1981). Reduction of intraocular pressure in normal and glaucomatous primate (Aotus trivirgatus) eyes by topically applied prostaglandin F.sub.2.alpha.. "Curr Eye Res" 1:205-209.
Camras, C. B., Podos S. M., Rosenthal J. S., Lee P. Y., Severin C. H. (1987a). Mulitple dosing of prostaglandin F.sub.2a or epinephrine on cynomolgus monkey eyes. I. Aqueous humor dynamics. Invest Ophthalmol Vis Sci 28:463-469.
Camras C. B., Bhuyan K. C., Podos S. M., Bhuyan D. K. Master R. W. P. (1987b) "Multiple Dosing of Prostaglandin F.sub.2.alpha. or epinephrine on cynomologus mokey eyes. II. Slitlamp biomicroscopy, aqueous humor analysis, and flourescein angiography." Invest. Ophthalmol. Vis. Sci 28:921-926.
Camras C. B., Siebold E. C., Lustgarten J. S., Serle J. B., Frisch S. C., Podos S. M., Bito L. Z. (1988) "Reduction of IOP by prostaglandin F.sub.2.alpha. -1-isopropyl ester topically applied in glaucoma patients", Ophthalmology 95(Supp.) 129 [This article is referrenced in the specification, and was raised as prior art in an opposition to Australian patent application 625096, which is related to the instant application. However, we have been unable to locate a copy of this article.].
Crawford K., Kaufman P. L. and True Gable, B. A. (1987), "Pilocarpine antagonizes PGF.sub.2.alpha. -induced ocular hypotension: Evidence for enhancement of uveoscleral outflow of PGF.sub.2.alpha. ". Invest. Ophthalmol. Vis. Sci. (Supp.) ARVO Abstracts 11.
Crawford, K. and Kaufman, P. L., (1987) "Pilocarpine Antagonizes Prostaglandin F.sub.2.alpha. -Induced Ocular Hypotension in Monkeys" Arch. Ophthamology 105 1112.
Flach A. J., Elisason J. A. (1988), "Topical prostaglandin E.sub.2 effects on normal human intraocular pressure". J. Ocu. Pharmacol. 4:13-18.
Gabelt, B. and Kaufman, P. L., (1989) "Prostaglandin F.sub.2.alpha. Increases Uvelscleral Outflow in the Cynomologus Monkey", Exp. Eye Res. 49 389-402.
Giuffre G. (1985). "The effects of prostaglandin F.sub.2.alpha. in the human eye." Graefes Arch Clin. Exp. Ophthalmol. 222:139-141.
Granstrom, E., (1975) "Metabolism of 17-Phenyl-18,19,20-Trinor-Prostaglandin F.sub.2.alpha. in the Cynomolgus Monkey and the Human Female", Prostaglandins 9:19-45.
Kaufman P. L. (1986). "Effects of intracamerally infused prostaglandins on outflow facility in cynomolgus monkey eyes with intact or retrodisplaced ciliary muscle." Exp. Eye Res. 43:819-827.
Kerstetter J. R., Brubaker R. F., Wilson S. E., Kullerstrand L. J. (1988). "Prostaglandin F.sub.2.alpha. -1-isopropylester lower intraocular pressure without decreasing aqueous humor flow." Am. J. Ophthalmol. 105:30-34.
Kirk-Othmar "Encyclopedia of Chemical Technology", 3d Ed. Supplement vol. 711-752 (1984).
Lee, P.-Y., Shae H., XZu L., Qu C.-K. (1988). "The effect of prostaglandin F.sub.2.alpha. on intraocular pressure in normotensive human subjects." Invest. Ophthalmol. Vis. Sci. 29:1474-1477.
Miller, "Biological Activities of 17-phenyl-18,19,20-trinorprostaglandins", Prostaglandins 9 9-18 (1975).
Nilsson, S. F. E., Stjernschantz J. and Bill A. (1987) "PGF.sub.2.alpha. increase uveoscleral outflow", Invest. Ophthalmol Vis. Sci. Suppl. 284.
Villumsen J. Alm A (1989) "Prostaglandin F.sub.2.alpha. isopropylester eye drops. Effects in normal human eyes." Br. J. Ophthalmol. 73:419-426.
Yankee, Chem Abst. 88:62048x, 1978.
Woodward et al., "Prostaglandin F.sub.2.alpha. Effects on IOP Negatively Correlate with Classical PGF.sub.2.alpha. -Receptor Stimulation" Presented in Eightly International Congress of Eye Research in San Francisco Sep. 4-8, 1988.
Woodward et al. (1989) "Prostaglandin F.sub.2.alpha. Effects on Intraocular Pressure Negatively Correlate with FP-Receptor Stimulation" Invest. Ophthal. 30 (8) 1838-1842.
Kirk-Othmar "Encyclopedia of Chemical Technology", 3d Ed. Supplement vol. 711-752 (1984).
Lee, P-Y, Shae H, XZu, L, Qu C-K (1988). "The effect of prostaglandin F.sub.2.alpha. on intraocular pressure in normotensive human subjects." Invest. Ophthalmol. Vis. Sci. 29:1474-1477.
Miller, "Biological Activities of 17-phenyl-18,19,20-trinorprostaglandins", Prostaglandins 9 9-18 (1975).
Nilsson SFE, Stjernschantz J. and Bill A. (1987) "PGF.sub.2.alpha. increase uveoscleral outflow." Invest. Ophthalmol Vis. Sci. Suppl. 284.
Villumsen J. Alm A (1989) "Prostaglandin F.sub.2.alpha. isopropylester eye drops. Effects in normal human eyes." Br. J. Ophthalmol. 73:419-426.
Yankee, Chem. Abst. 88:62048x, 1978.
Woodward et al., "Prostaglandin F.sub.2.alpha. Effects of IOP Negatively Correlate with Classical PGF.sub.2.alpha. -Receptor Stimuluation" Presented in Eightly International Congress of Eye Research in San Francisco Sep. 4-8, 1988.
Woodward et al. (1989) "Prostaglandin F.sub.2.alpha. Effects on Intraocular Pressure Negatively Correlate with FP-Receptor Stimulation" Invest. Ophthal. 30(8) 1838-1842.
Camras C. B., Bito L. Z. and Eakins K. E. (1977): "Reduction of intraocular pressure by prostaglandins applied to the eyes of concious rabbits", Invest Ophthalmol Vis. Sic, 16:1125.
Kerstetter J. R., Brubaker R. F., Wilson S. E. and Kullerstrand L. (1988) "Prostaglandin F2.sub..alpha. -1-Isopropylester Lowers Intracolor Pressure Without Decreasing Aqueous Humor Flow". Am. J. Ophthalmology 105:30-34.
Bito, Baroody and Miranda (1987): "Eicosanoids as a new class of ocular Hypotensive agents. The apparent therapeutic advantage of derived Prostaglandins of the A and B type as compared with primary prostaglandins of the E, F and D types", Experimental Eye Research, 44:825.
Villumser, J., Alm A., Soderstrom M., (1989) "Prostaglandin F2.sub..alpha. -isopropylester Eye Drops: Effect on Intraocular Pressure in Open Angle Glaucoma". Brit. J. Ophthalmology 73, 975-79.
Ritch, Shields and Krupin (1989): "The Glaucomas", C. V. Mosby, p. 561.
Supplement to Investigative Ophthalmology and Visual Science 22 39 (1982), L. Z. Bito, A. Draga, J. Blanco, and C. B. Camras, "Maintenance of Reduced Intraocular Pressure (IOP) for several months by topical application of prostaglandin (PG) E.sub.1 ti Eyes of Trained Cats".
Starr, M. S. (1971) "Further studies on the effect of prostaglandin on intraocular pressure in the rabit", Exp. Eye, Res. 11:170.
Kass,

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