Harness for working animal
Patent
1978-04-26
1980-11-18
Demers, Arthur P.
Harness for working animal
542426, 542429, 542430, 542441, 2603436, C07D30720, C07D40712
Patent
active
042347203
ABSTRACT:
Prostaglandin type compounds of the formula ##STR1## where X is CH.sub.2 --CH.sub.2, CH.dbd.CH cis or C.tbd.C; Y is CH.sub.2 or O; Z is H, OH, CH.sub.3 or CH.sub.2 OH and R is a linear, branched or cyclo alkyl chain of 3 to 7 carbon atoms, can be prepared by essentially a one-step reaction from a new intermediate of the formula ##STR2## where R represents a linear, branched or cyclo alkyl group of 3 to 7 carbon atoms; P is a removable protective group and z is H, OP,CH.sub.3 or CH.sub.2 OP.
The intermediate is useful in making known and new PGEs useful as antihypertensives, gastric acid secretion inhibitors and smooth muscle stimulants.
REFERENCES:
Corey et al., J.A.C.S. 95 (1973) pp. 6832-6833.
Corey et al., J.A.C.S. 94 (1972) pp. 7210-7211.
Corey et al., J.A.C.S. 90 (1968) pp. 5615-5616.
Ishizuka Naoyasu
Nakamoto Hiromasa
Pernet Andre G.
Abbott Laboratories
Burgauer Paul D.
Demers Arthur P.
Niblack Robert L.
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