Prostaglandin derivatives

Details Prostaglandin derivatives Prostaglandin derivatives

1976-12-23

1978-09-26

Morgenstern, Norman

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603457P, 2603458P, 2603459P, 2604482B, 260590C, 560 9, 560 53, 560118, 560121, 562500, 562503, 562463, 542426, 542429, 07C 4982, C07C 4928, C07C 4946, C07D30906

Patent

active

041170148

ABSTRACT:
Prostaglandin type compounds of the formula ##STR1## wherein X is --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH-cis or--C.tbd.C--; Y is CH.sub.2 or O; Q is--CH.sub.2 --CH.sub.2 --or --CH.dbd.CH--; Z is H, OH, CH.sub.3 or CH.sub.2 OH, R is a linear, branched or cyclo alkyl chain of 3 to 7 carbon atoms or certain other moieties, and R" and R'''are H or CH.sub.3. These compounds are prepared by essentially a one-step reaction from a new intermediate of the formula ##STR2## wherein Z, R, R" and Q have the above meaning and P is a removable protective group by condensation with a reactive moiety introducing the entire .alpha.-chain (R'''=CH.sub.3). If desired, the carbonyl function is subsequently reduced to W= --CH(OH)--. The intermediate is useful in making known and new PGEs useful as antihypertensives, gastric acid secretion inhibitors and smooth muscle stimulants.

REFERENCES:
patent: 3873571 (1975-03-01), Kelly
patent: 3892733 (1975-07-01), Brown
patent: 3923872 (1975-12-01), Caton
patent: 3966792 (1971-06-01), Hayashi et al.
patent: 3975442 (1976-08-01), Hajos et al.
patent: 3981891 (1976-09-01), Celli
patent: 4032576 (1977-06-01), Nelson

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