Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1978-04-26
1980-02-12
Rotman, Alan L.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
542429, 424279, C07D30732
Patent
active
041883314
ABSTRACT:
Prostaglandin type compounds of the formula ##STR1## where X is CH.sub.2 --CH.sub.2, CH.dbd.CH or C.tbd.C; Y is CH.sub.2 or O; Z is OH, CH.sub.3 or CH.sub.2 OH, R" is H or loweralkyl and R is a linear, branched or cyclic alkyl group of 3 to 7 carbon atoms, can be prepared by essentially a one-step reaction from a new intermediate of the formula ##STR2## wherein R' is hydrogen, R and Z are the same as shown above, and P is a removable protective group. The new compounds are useful as antihypertensives, gastric acid secretion inhibitors and smooth muscle stimulants.
REFERENCES:
patent: 3873607 (1975-03-01), Bernady et al.
patent: 3883659 (1975-05-01), Vlattas
Ishizuka Naoyasu
Nakamoto Hiromasa
Pernet Andre G.
Abbott Laboratories
Burgauer Paul D.
Harkaway Natalia
Niblack Robert L.
Rotman Alan L.
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