Prostaglandin derivatives

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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542429, 424279, C07D30732

Patent

active

041883314

ABSTRACT:
Prostaglandin type compounds of the formula ##STR1## where X is CH.sub.2 --CH.sub.2, CH.dbd.CH or C.tbd.C; Y is CH.sub.2 or O; Z is OH, CH.sub.3 or CH.sub.2 OH, R" is H or loweralkyl and R is a linear, branched or cyclic alkyl group of 3 to 7 carbon atoms, can be prepared by essentially a one-step reaction from a new intermediate of the formula ##STR2## wherein R' is hydrogen, R and Z are the same as shown above, and P is a removable protective group. The new compounds are useful as antihypertensives, gastric acid secretion inhibitors and smooth muscle stimulants.

REFERENCES:
patent: 3873607 (1975-03-01), Bernady et al.
patent: 3883659 (1975-05-01), Vlattas

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