Prostaglandin derivatives

Details Prostaglandin derivatives Prostaglandin derivatives

1988-01-29

1989-03-14

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514389, 514452, 514530, 544 39, 548313, 549363, 560119, 560121, C07C17700, A61K 31557

Patent

active

048124575

ABSTRACT:
Permeability characterized in that the carboxy group at 1-position of the prostaglandin is combined with a cell membrane permeable substance having hydroxy group or amino group through the intermediation of an ester bond to the hydroxy group or an amide bond to the amino group are novel and have improved cell membrane permeability.

REFERENCES:
Kirk-Othmer, Encylopedia of Chemical Technology, 3rd Ed., Supplement vol. 1984, pp. 711-752.
Chem. Abstr., vol. 96, No. 19, p. 178, abstract No. 156368u, 5/82.
Chem. Abstr. vol. 97. No. 7, p. 252, abstract No. 51485x, 8/82.
Hatsumi, J of Chrom. 253, 271 (1982).

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