Prostaglandin combinations in glaucoma therapy

Details Prostaglandin combinations in glaucoma therapy Prostaglandin combinations in glaucoma therapy

1982-02-04

1992-12-22

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514573, 514913, A61K 31215, A61K 3119, A61K 31557

Patent

active

051735075

ABSTRACT:
Disclosed is the use of combinations of the prostaglandins PGF.sub.2.alpha. and PGE.sub.2 and their respective derivatives, and pharmaceutically accceptable salts and esters thereof in the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic, pharmaceutical compositions comprising said combinations.

REFERENCES:
patent: 4029681 (1977-06-01), Smith
patent: 4288616 (1981-09-01), Sih
The Merck Index, 10th Edition (1983) p. 1135.
Kennedy et al., Advances in Prostaglandin, Thromboxane and Leukotriene Research, vol. II, (1983) pp. 327-332.
Dong et al, "Effects of Prostaglandins and Thromboxane Analogues on Bullock and Dog Iris Sphincter Preparations" The MacMillan Press, Ltd. 1982.
Sardar et al., J. Pharm. and Exp. Therp 247: 1064-1072 (1988).

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