Prostaglandin cathartic

Details Prostaglandin cathartic Prostaglandin cathartic

1992-12-30

1994-05-31

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514573, 560121, 562503, A61K 31557

Patent

active

053170326

ABSTRACT:
The present invention relates to cathartics comprising 15-keto-16-halogen-PGs as an essential ingredient without substantive side-effects; the catharic effect is thought mainly caused by an enteropooling effect.

REFERENCES:
patent: 4163016 (1979-07-01), Holland et al.
patent: 4212993 (1980-07-01), Holland et al.
patent: 4260818 (1981-04-01), Holland et al.
patent: 4306078 (1981-12-01), Holland
patent: 4374856 (1983-02-01), Ruwart
patent: 4410720 (1983-10-01), Holland
patent: 5166178 (1992-11-01), Veno
Robert, et al., "Enteropooling Assay: A Test for Diarrhea Produced by Prostaglandins", Prostaglandin, May 1986, vol. 11, No. 5, p. 809.
10th Annual Meeting of Nippon Ensho Gakkai (Jul. 20-21 1989), Abstract of "Effects of Lipo-PGE.sub.1 on Renal Diseases: On and Around the Effect on Creatinine Clearance (Ccr)."
Zurier, et al., "Prostaglandin E.sub.1 Treatment of NZB/NZW Mice", Arthritis and Rheumatism, vol. 20, No. 2 (Mar. 1977) p. 723.

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