Prostaglandin analogues, processes for their preparation and pha

Details Prostaglandin analogues, processes for their preparation and pha Prostaglandin analogues, processes for their preparation and pha

1992-01-23

1993-06-22

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548452, A61K 3140, C07D20952

Patent

active

052216896

ABSTRACT:
The present invention relates to novel isomers of 6,9.alpha.-nitrilo-PGI.sub.1 s having a specific steric configuration, which are replaced by an alkyl (C.sub.1 to C.sub.8)-substituted cycloalkyl (C.sub.4 to C.sub.7) group in (1S,S) form, in (1S,R) form or in cis form at the 15-, 16- or 17-position of the PG skeleton, and, alkyl esters thereof, non-toxic salts thereof, non-toxic acid addition salts thereof and cyclodextrin clathrates thereof, possessing more potent PG-like pharmacological activity than other isomers.

REFERENCES:
patent: 4180675 (1979-12-01), Hayashi
patent: 4220795 (1980-09-01), Kluendes
patent: 4234597 (1980-11-01), Hayashi
patent: 4275075 (1981-06-01), Kurono
patent: 4278088 (1981-07-01), Hyayashi
patent: 4479966 (1984-10-01), Hayashi
patent: 4562207 (1985-12-01), Imaki
Imaki, Adv. Prost. Res. 19, pp. 666-669 (1988).

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