Prostaglandin analogues

Details Prostaglandin analogues Prostaglandin analogues

1978-07-13

1980-06-17

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

26034622, 260456P, 536103, 542426, 560 5353, 560118, 562463, 562465, 562500, 424308, 424317, C07C17700, A61K 3119, A61K 31215

Patent

active

042084288

ABSTRACT:
The invention relates to prostaglandin analogues of the general formula: ##STR1## (wherein A represents a grouping of the formula: ##STR2## B represents an alkylene group containing from 1 to 7 carbon atoms or a group ##STR3## (wherein the group --(CH.sub.2).sub.n --may be attached to the ortho, meta or para position of the phenyl ring and m and n, which may be the same or different, each represent an integer from 1 to 5 inclusive, the sum of the integers represented by m and n being from 2 to 6 inclusive), X represents ethylene or cis-vinylene, Y represents ethylene or trans-vinylene, W represents ethylene or trans-vinylene, Z represents a halogen atom, and R.sup.1 represents a hydrogen atom or an alkyl group containing from 1 to 12 carbon atoms) and cyclodextrin clathrates of such acids and esters and, when R.sup.1 represents a hydrogen atom, non-toxic salts thereof, which possess characteristic prostaglandin-like properties.

REFERENCES:
patent: 3997588 (1976-12-01), Mueller
patent: 4117119 (1978-09-01), Kurono et al.

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