Prostaglandin analogs and process of preparation thereof

Details Prostaglandin analogs and process of preparation thereof Prostaglandin analogs and process of preparation thereof

1981-04-02

1982-07-06

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568347, 568348, 568352, 568379, 568420, C07C 49597, C07C 4545

Patent

active

043384668

ABSTRACT:
Prostaglandin analogs and process for the preparation thereof as precursors or the synthesis of oligomeric mixtures exhibiting biological activity for protection of oxidative phosphorylation of degraded mitochondria. The analogs have the general formula: ##STR1## synthesized by O-alkylating a 2-alkylcyclopentane-1,3-dione to form an enol ether, reacting the ether with CH.sub.2 .dbd.CHMgBr to form a vinyl, oxidizing the vinyl with OsO.sub.4 and NaIO.sub.4 to form an aldehyde, and reacting the aldehyde with a sodium salt of dimethyl (2-oxoalkyl)phosphonate.

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patent: 4053341 (1977-11-01), Naipawer et al.
patent: 4073799 (1978-02-01), Kondo et al.
patent: 4153808 (1979-05-01), Polis et al.
patent: 4245111 (1981-01-01), Polis et al.
Fieser et al., "Reagents for Organic Synthesis", pp. 193 and 420 (1967).

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