Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1992-09-11
1995-04-25
Gerstl, Robert
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
514104, 548413, 560 17, 560 22, 560160, 562 13, C07F 938, A61K 3166
Patent
active
054099110
ABSTRACT:
This invention relates to a prostaglandin-bisphosphonate compound of the formula: ##STR1## and its pharmaceutically acceptable salts. The claimed compounds are effective as delivery agents of prostaglandins to treat osteoporosis and related bone diseases. The claimed compounds also simultaneously deliver a bisphosphonate which inhibits bone resorption and delivers prostaglandins which increase bone formation in vivo.
REFERENCES:
patent: 3927197 (1975-12-01), Monkhouse
patent: 3975404 (1976-08-01), Lincoln
patent: 4018892 (1977-04-01), Walsh
patent: 4097601 (1978-06-01), Schaff
patent: 4171331 (1979-10-01), Biddlecom et al.
patent: 4621100 (1986-11-01), Lund et al.
patent: 4761406 (1988-08-01), Flora et al.
patent: 4921697 (1990-05-01), Peterlik et al.
patent: 5071655 (1991-12-01), Baylink
patent: 5118667 (1992-06-01), Adams et al.
Klenner et al. "Anticancer-agent-linked phosphonates with antisteolytic and anti plastic properties: a promising perspective in the treatment of bone-related malignancies?" J. Cancer Res. Clin. Oncol. 116:341-350 (1990).
Frost et al. "Treatment of Osteoporosis by Manipulation of Coherent Bone Cell Populations" Clinical Orthopedics and Related Research, 143, 227 (1979).
Harvey and Bennet "Prostaglandins in Bone Resorption" CRC Press, p. 37 (1988).
Rodan, G. "Cellular Approaches to Therapy for the Prevention and Treatment of Osteoporosis" J. Cell Biochem. Suppl. 0 (15, Part F), 160 (1991).
Ueno et al., "The Effects of Prostaglandin E.sub.2 in Rapidly Growing Rats" Bone, 6, 79-86 (1985).
Jee et al., "Long-term anabolic effects of prostaglandin-E.sub.2 on tibial diaphyseal bone in male rats:" Bone and Mineral, 15, 33-55 (1991).
Jee et al., "The Effects of Prostaglandin E.sub.2 in Growing Rats: Increased Metaphyseal Hard Tissue and Cortico-Endosteal Bone Formation" Calf. tissue Int 37:148-157 (1985).
Raisz et al. "Hormonal Control of Skeletal Growth" Ann. Rev. Physiol. 43:225 (1981).
Rodan Gideon A.
Tyler Peter C.
Young Robert N.
Gerstl Robert
Giesser Joanne M.
Matukaitis Paul D.
Merck & Co. , Inc.
Winokur Melvin
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