Prostacyclins, their analogs or prostaglandins and thromboxane a

Details Prostacyclins, their analogs or prostaglandins and thromboxane a Prostacyclins, their analogs or prostaglandins and thromboxane a

1990-04-02

1996-06-04

Criares, Theodore J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514467, 514572, 514573, A61K 31355, A61K 3134, A61K 3119

Patent

active

055233210

ABSTRACT:
Combination products containing a prostaglandin (PG), prostacyclin (PC) or a prostacyclin analog (PCA) and a thromboxane receptor antagonist (TXAA) are suitable for joint application to thrombotic and thromboembolic syndromes.

REFERENCES:
patent: 4029814 (1977-06-01), Bundy
patent: 4048328 (1977-09-01), Abraham et al.
patent: 4263207 (1981-04-01), Rokach et al.
patent: 4472586 (1984-09-01), Hamel et al.
patent: 4680307 (1987-07-01), Muraoka et al.
Potentiation of the Inhibitory Effect of a Thromboxane A.sub.2 Antagonist (L-640,035) on Arterial Thrombosis Formation in Rabbit By The Angiotensin converting Enzyme Inhibitor Enalapril, Chi-Chung Chan and Anthony Ford-Hutchinson, European Journal of Pharmacology, 110 (1985) pp. 323-328.
International Dictionary of Medicine and Biology, vol. 1, John Wiley & Sons, 1986, p. 781, and vol. 11, p. 1296.
W. Witt et al., "Synergistic Antiplatelet and Antithrombotic Effects of a Prostacyclin Analogue (Iloprost) Combined with a Thromboxane Antagonist (Sulotroban) in Guinea Pigs and Rats", Thrombosis Research 51; 607-616 (1988).
S. Stuerzebecher et al., "The PGI.sub.2 -Analogue Iloprost and the TXA.sub.2 -Receptor Antagonist Sulotroban Synergistically Inhibit TXA.sub.2 -Dependent Platelet Activation", Prostaglandins, vol. 36, No. 6, pp. 751-760 (Dec. 1988).

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