Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1985-11-20
1987-10-06
Gerstl, Robert
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
514573, 536 46, 560 53, 560 56, 560116, 560119, 562462, 562466, 562498, 562501, C07C17700, A61K 31557
Patent
active
046983635
ABSTRACT:
Prostaglandin analogues of the formula: ##STR1## (wherein R.sup.1 represents a hydrogen atom or an aliphatic or alicyclic hydrocarbon radical, Y.sup.1 represents a carbonyl or hydroxymethylene group, A.sup.1 represents an alkylene linkage containing 1, 2 or 3 carbon atoms and optionally bearing a methyl or ethyl substituent, R.sup.2 represents a hydrogen atom or a methyl or ethyl group and R.sup.3 represents a hydrogen atom or R.sup.2 and R.sup.3 form an alkylene linkage containing 2 or 3 carbon atoms, optionally bearing a methyl or ethyl substituent, such that the symbols A.sup.1, R.sup.2 and R.sup.3, together with the carbon atoms through which they are connected, may form a cycloalkyl ring of 5, 6, 7 or 8 carbon atoms, optionally bearing one or two methyl or ethyl substituents, or A.sup.1 and R.sup.3, together with the carbon atom through which they are connected, may form a phenylene ring optionally substituted by a halogen atom or by a trifluoromethyl group or by a straight- or branched-chain alkyl or alkoxy group containing from 1 to 6 carbon atoms, A.sup.2 represents a direct bond or a methylene group optionally bearing one or two methyl or ethyl substituents, X.sup.1 represents an ethylene, transvinylene or ethynylene group, Y.sup.2 represents a carbonyl or hydroxymethylene group, and either (i) A.sup.3 represents a straight- or branched-alkylene chain containing from 1 to 5 carbon atoms, Z.sup.1 represents a direct bond or an oxygen or sulphur atom, and R.sup.4 represents a group R.sup.4' which is an aliphatic or alicyclic hydrocarbon radical, or R.sup.4 represents a phenyl group optionally substituted by a halogen atom or by a trifluoromethyl group or by a straight- or branched-chain alkyl or alkoxy group containing from 1 to 6 carbon atoms, or (ii) A.sup.3 and Z.sup.1 both represent direct bonds and R.sup.4 represents a group R.sup.4' as hereinbefore defined) and cyclodextrin clathrates thereof and non-toxic salts thereof possess useful pharmacological properties.
REFERENCES:
patent: 4192891 (1980-03-01), Haslanger
patent: 4517202 (1985-05-01), Bird
Gerstl Robert
May & Baker Limited
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